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Table 3 Integrated Peak Areas of Metabolites Identified from Blood Samples in Adolescents with Juvenile Arthritis vs Controls

From: Serine, N-acetylaspartate differentiate adolescents with juvenile idiopathic arthritis compared with healthy controls: a metabolomics cross-sectional study

Metabolite

JIA

Control

∆ (JIA Relative to Control)

Mean

SD

Mean

SD

Mean Difference

% Difference

2-hydroxypyridine

.

.

3.98e+ 5

2.13e+ 5

−3.98e+ 05

**

3-aminoisobutanoate

.

.

7.05e+ 7

1.81e+ 7

−7.05e+ 07

**

3-hydroxykynurenine

6.09e+ 5

2.41e+ 5

6.86e+ 5

4.14e+ 5

− 7.70e+ 04

−11%

3-methylglutaric acid

3.57e+ 6

9.5e+ 5

.

.

+ 3.57e+ 06

**

3-ureidopropionate

.

.

2.77e+ 6

5.71e+ 5

−2.77e+ 06

**

4-guanidinobutanoate

1e+ 6

5.61e+ 5

9.98e+ 5

8.23e+ 5

+ 2.00e+ 03

0%

5, 6-dihydrouracil

1.11e+ 7

1.76e+ 6

1.12e+ 7

1.47e+ 6

−1.00e+ 05

− 1%

5-aminolevulinic acid

.

.

1.87e+ 7

6.05e+ 6

−1.87e+ 07

**

5-methylcytosine

5.95e+ 5

2.05e+ 5

6.38e+ 5

2.19e+ 5

−4.30e+ 04

−7%

5-oxolproline

3.25e+ 8

6.39e+ 7

3.38e+ 8

4.92e+ 7

−1.30e+ 07

− 4%

Acetyl-carnitine

1.13e+ 9

3.66e+ 8

1.31e+ 9

3.3e+ 8

−1.80e+ 08

− 14%

Acetyl-lysine

5.41e+ 5

2.7e+ 5

.

.

+ 5.41e+ 05

**

Adenine

5.18e+ 5

1.77e+ 5

4.99e+ 5

2.81e+ 5

+ 1.90e+ 04

4%

Alpha-glucose

2.93e+ 7

3.85e+ 6

3.71e+ 7

7.42e+ 6

−7.80e+ 06

−21%±

Alpha-ketoglutarate

3.38e+ 7

7.64e+ 6

4.63e+ 7

7.85e+ 6

−1.25e+ 07

− 27%±

Arginine

1.05e+ 8

2.42e+ 7

1.02e+ 8

1.79e+ 7

+ 3.00e+ 06

3%

Asparagine

1.11e+ 7

3.07e+ 6

1.06e+ 7

3.25e+ 6

+ 5.00e+ 05

5%

Beta-alanine

1.82e+ 8

3.74e+ 7

1.87e+ 8

3.66e+ 7

− 5.00e+ 06

−3%

Betaine

7.47e+ 8

2.29e+ 8

7.93e+ 8

1.97e+ 8

−4.60e+ 07

−6%

Carnitine

1.35e+ 9

2.04e+ 8

1.28e+ 9

1.44e+ 8

+ 7.00e+ 07

5%

Citrate

5.11e+ 8

1.44e+ 8

7.66e+ 8

1.85e+ 8

−2.55e+ 08

−33%

Citrulline

4.7e+ 7

8.54e+ 6

5.43e+ 7

9.93e+ 6

−7.30e+ 06

−13%

CMP

3.81e+ 5

3.12e+ 5

.

.

+ 3.81e+ 05

**

Creatine

4.2e+ 8

1.74e+ 8

4.05e+ 8

1.78e+ 8

+ 1.50e+ 07

4%

Creatinine

3.39e+ 8

5.66e+ 7

3.41e+ 8

5.12e+ 7

−2.00e+ 06

−1%

Cystine

8.58e+ 6

3.66e+ 6

4.51e+ 6

1.65e+ 6

+ 4.07e+ 06

90%±

Cytidine

7.85e+ 5

5.72e+ 5

5.91e+ 5

5.59e+ 5

+ 1.94e+ 05

33%

Deoxycarnitine

8.06e+ 7

1.35e+ 7

7.71e+ 7

1.44e+ 7

+ 3.50e+ 06

5%

Fumarate

1.93e+ 6

5.89e+ 5

2.21e+ 6

6.47e+ 5

−2.80e+ 05

−13%

Glutamic acid

.

.

1.36e+ 7

3.98e+ 6

−1.36e+ 07

**

Glutamine

2.88e+ 8

3.8e+ 7

3.06e+ 8

4.28e+ 7

−1.80e+ 07

−6%

Glutarate

3.39e+ 6

2.07e+ 6

.

.

+ 3.39e+ 06

**

Glycerol

2.14e+ 7

1.01e+ 7

2.6e+ 7

9.92e+ 6

−4.60e+ 06

−18%

Glycine

1.73e+ 7

5e+ 6

1.26e+ 7

2.36e+ 6

+ 4.70e+ 06

37%±

Guanosine

7.21e+ 6

3.28e+ 6

7.07e+ 6

3.66e+ 6

+ 1.40e+ 05

2%

Histidine

5.09e+ 7

6.42e+ 6

5.64e+ 7

8.73e+ 6

−5.50e+ 06

−10%

Homocysteine

1.96e+ 7

1.42e+ 7

2.52e+ 7

1.71e+ 7

− 5.60e+ 06

−22%

Inosine

4.76e+ 7

2.18e+ 7

4.66e+ 7

2.57e+ 7

+ 1.00e+ 06

2%

Isocitric acid

.

.

1.93e+ 7

3.82e+ 6

−1.93e+ 07

**

Isoleucine

3.51e+ 9

4.35e+ 8

3.63e+ 9

6.72e+ 8

−1.20e+ 08

−3%

Kynurenine

8.73e+ 6

3.14e+ 6

1.06e+ 7

1.23e+ 7

−1.87e+ 06

− 18%

Lactate

1.76e+ 9

4.64e+ 8

2.16e+ 9

6.69e+ 8

−4.00e+ 08

− 19%

Leucine

7.31e+ 9

6.18e+ 8

7.84e+ 9

1.38e+ 9

−5.30e+ 08

−7%

Lysine

.

.

1.54e+ 8

1.7e+ 7

−1.54e+ 08

**

Malate

3.15e+ 7

6.73e+ 6

3.86e+ 7

5.71e+ 6

−7.10e+ 06

−18%

Methionine

1.15e+ 9

1.51e+ 8

1.22e+ 9

1.37e+ 8

−7.00e+ 07

−6%

Methyl-histidine

1.28e+ 7

6.66e+ 6

1.03e+ 7

5.64e+ 6

+ 2.50e+ 06

24%

Myristic acid

2.21e+ 5

1.5e+ 5

3.69e+ 5

1.35e+ 5

−1.48e+ 05

−40%

N-acetyl-alanine

.

.

1.17e+ 7

1.1e+ 6

−1.17e+ 07

**

N-acetyl-aspartate

1.5e+ 6

2.34e+ 5

3.01e+ 6

4.5e+ 5

−1.51e+ 06

−50%±

N-acetyl-glycine

1.68e+ 7

8.35e+ 6

1.84e+ 7

6.24e+ 6

−1.60e+ 06

− 9%

N-acetyl-methionine

1.82e+ 6

7.04e+ 5

1.75e+ 6

3.67e+ 5

+ 7.00e+ 04

4%

N-acetyl-phenylalanine

1.69e+ 5

1.31e+ 5

.

.

+ 1.69e+ 05

**

N-acetyl-putrescine

2.11e+ 6

3.79e+ 5

2.33e+ 6

5.17e+ 5

−2.20e+ 05

−9%

N-acetyl-serine

3.97e+ 6

5.16e+ 5

4.5e+ 6

6.29e+ 5

−5.30e+ 05

−12%

Ornithine

5.41e+ 7

1.61e+ 7

.

.

+ 5.41e+ 07

**

Pantothenic acid

7.56e+ 6

4.02e+ 6

7.23e+ 6

2.64e+ 6

+ 3.30e+ 05

5%

Phenylalanine

4.68e+ 9

3.38e+ 8

5.01e+ 9

4.1e+ 8

−3.30e+ 08

−7%

Pipecolate

2.97e+ 8

1.77e+ 8

3.73e+ 8

3.56e+ 8

− 7.60e+ 07

− 20%

Proline

1.56e+ 9

3.41e+ 8

1.89e+ 9

5.3e+ 8

− 3.30e+ 08

−17%

Pyridoxal

.

.

8.56e+ 5

3.82e+ 5

−8.56e+ 05

**

Ribose-5-phosphate

7.47e+ 5

2.63e+ 5

7.62e+ 5

2.44e+ 5

−1.50e+ 04

−2%

Serine

2.76e+ 5

1.36e+ 5

7.47e+ 6

1.21e+ 6

−7.19e+ 06

−96%±

Spermidine

8.1e+ 6

4.13e+ 6

7.77e+ 6

4.17e+ 6

+ 3.30e+ 05

4%

Succinate

4.36e+ 7

1e+ 7

4.88e+ 7

9.73e+ 6

−5.20e+ 06

−11%

Taurine

.

.

9.82e+ 6

3.41e+ 6

−9.82e+ 06

**

Theobromine

2.04e+ 8

4.93e+ 8

.

.

+ 2.04e+ 08

**

Threonine

8.05e+ 7

1.99e+ 7

8.39e+ 7

1.4e+ 7

−3.40e+ 06

−4%

Trans-aconitate

2.32e+ 6

8.61e+ 5

2.85e+ 6

7.49e+ 5

−5.30e+ 05

−19%

Tyrosine

2.07e+ 9

3.15e+ 8

2.31e+ 9

3.45e+ 8

−2.40e+ 08

− 10%

Uracil

1.49e+ 6

4.72e+ 5

2.03e+ 6

5.37e+ 5

−5.40e+ 05

− 27%

Urocanate

8.31e+ 6

5.09e+ 6

9.99e+ 6

6.89e+ 6

−1.68e+ 06

− 17%

  1. ±adjusted p < 0.05
  2. **detected in one group only