Table 2 Summary of the therapeutic effects of different protocals for NLRP12-AID

Colchicine

10/M (twins)

NK

↓ Fever(≈38 °C) but NE on the frequency of episodes

[17]

9/F

NK

NE

9/M

NK

NE

[36]

Corticosteroids

9/F

Oral administration

↓Length of febrile episodes(3 ~ 5d)

[17]

2 m-13y/F

Short courses(1-3d)

Shorter and milder fever episodes but not CR

[34]

9/F

Prednisolone (1.5 mg/kg by mouth daily) and methotrexate (10 mg/m2 by mouth weekly)

Inflammatory parameters are still abnormal, but without any symptoms

[39]

3/F

prednisolone(dose NK)

CR

[33]

17/F

prednisolone(up to 50 mg/daily)

CR

[33]

4/F

Prednisolone

Good response

[37]

NSAIDs

3/F

NK

PR

[33]

17/F

NK

PR

[33]

NSAIDs+Corticosteroids

9/M

Naproxen+prednisolone(15 mg/day×7d, and once when paroxysms started)

PR

[36]

Anakinra

17/F

100 mg/daily

CR

[33]

6/M

1 mg/kg/day

CR

[35]

10/M(twins)

1 mg/kg/day

CR in 2 months but relapse in 14 months

[11]

Canakinumab

2 m-13y/F

From 2 mg/kg every 8 weeks to 5 mg/kg every 4 weeks

Resolution of the rash, abdominal pain and arthralgia; fever episodes became rare and very mild

[34]

6/M

2 mg/kg/month

CR

[35]

TNF inhibitors (adalimumab and infliximab)

2 m-13 y/M

NK

Shorter and milder fever episodes but not CR

[34]