Proteomics based markers of clinical pain severity in juvenile idiopathic arthritis

Table 1 Proteins vs. Clinical Pain Level. Proteins identified in serum of JIA patients demonstrating significant (p < 0.05) association to clinical pain levels with corresponding function. Samples sizes of N = 14* or N = 15** were present for all proteins

Proteins Related to Pain	Function	Spearman Correlation Coefficient (r)	P-value (two-tailed)	95% confidence interval
IGLV3.9*	Immunoglobulins: Humoral immunity	−0.70	0.007	−0.90 to − 0.25
IGHG4**	Immunoglobulins: Humoral immunity	−0.60	0.020	−0.86 to − 0.11
IGKV1.5**	Immunoglobulins: Humoral immunity	0.54	0.040	−0.83 to − 0.023
IGKV3D.15**	Immunoglobulins: Humoral immunity	0.59	0.024	−0.85 to − 0.091
IGHV3.72**	Immunoglobulins: Humoral immunity	−0.54	0.041	−0.83 to − 0.018
IGHV3.74	Immunoglobulins: Humoral immunity	−0.72	0.004	−0.902 to − 0.31
LGALS3BP**	Promotes integrin-mediated cell adhesion: Immune response	0.52	0.049	−0.005 to 0.82
ANG**	Role in angiogenesis and autoimmune response, suggested to play a role in immune-mediated inflammatory response	−0.53	0.046	−0.82 to − 0.002
PRG4**	Role in boundary lubrication within articulating joints, involved in vesicle-mediated transport in immune responses	0.65	0.011	0.183 to 0.874
CST3*	Cystatin C: Inhibition of cysteine proteases, involved in inflammation and immune regulation, vascular remodeling and cell migration	−0.58	0.033	−0.85 to − 0.050
VWF**	Hemostasis, thrombosis and vascular inflammation	−0.55	0.035	−0.84 to − 0.038
ALB**	Regulate osmotic pressure	0.57	0.028	−0.84 to − 0.067
AGT**	Angiotensinogen: Blood pressure and fluid and salt regulation	0.55	0.035	0.041 to 0.84
BTD**	Enzyme biotinidase: Biotin removal from food	0.53	0.045	0.005 to 0.824

ISSN: 1546-0096