Immunoprofiling of active and inactive systemic juvenile idiopathic arthritis reveals distinct biomarkers: a single-center study

Table 1 Clinical characteristics of sJIA patients at the sampling time points

Patient #	Sex	Disease duration at sampling (months)	Sampling Age (years)	Symptoms at sampling	CRP (mg/dL)	Treatments at sampling	Treatments duration at sampling (months)	Analysis groups
Patient #	Sex	Disease duration at sampling (months)	Sampling Age (years)	Symptoms at sampling	CRP (mg/dL)	Treatments at sampling	Treatments duration at sampling (months)	Active	Inactive	Paired
1	M	15	3	arthritis	16	Prednisolone, MTX, Adalimumab	8, 15, 15	Yes		Yes
1	M	24	4	NS	1	Tocilizumab, MTX	9, 24		Yes	Yes
2	F	1	3	arthritis	87	Ibuprofen	1	Yes		Yes
2	F	14	4	NS	< 1	NT			Yes	Yes
3	M	4	4	fever, arthritis	193	Prednisolone	4	Yes		Yes
3	M	81	7	NS	< 1	Canakinumab	26		Yes	Yes
4	M	21	5	arthritis, fever, hepatomegaly, splenomegaly	123	MTX, Prednisolone, Canakinumab	1, 1, 7	Yes		Yes
4	M	27	6	NS	NA	Canakinumab	13		Yes	Yes
5	M	1	9	fever, splenomegaly, enthesopathy	52	Prednisolone	1	Yes		Yes
5	M	4	10	NS	1	Canakinumab, Prednisolone	3, 4		Yes	Yes
6	M	76	7	arthritis	< 1	NT		Yes		Yes
6	M	105	10	NS	< 1	MTX, Tocilizumab	36, 44		Yes	Yes
7	M	57	13	NS^*	35	Tocilizumab	39	Yes		Yes
7	M	72	14	NS	1	Tocilizumab	54		Yes	Yes
8	F	63	14	fever, arthritis	33	Etanercept	12	Yes		Yes
8	F	66	14	NS	9	Prednisolone, Canakinumab	2, 2		Yes	Yes
9	F	32	7	rash, arthritis	< 1	Prednisolone, Tocilizumab	1, 24	Yes		Yes
9	F	113	13	NS	1	NT			Yes	Yes
10	F	3	10	fever, rash	1	Prednisolone	1	Yes
11	M	1	10	fever, rash	21	NT		Yes
12	M	30	14	arthritis	34	Anakinra	25	Yes
13	F	23	16	fever	71	NT		Yes
14	F	7	16	arthritis	< 1	Tocilizumab, MTX	3, 6	Yes
15	F	47	6	NS	< 1	Canakinumab, MTX	3, 47		Yes
16	M	5	8	NS	1	Prednisolone	4		Yes
17	M	2	8	NS	NA	Prednisolone	1		Yes
18	F	85	11	NS	1	NT			Yes
19	F	95	13	NS	< 1	Anakinra, Prednisolone	5, 43		Yes
20	F	2	13	NS	1	Prednisolone	1		Yes
21	F	9	13	NS	NA	Prednisolone	8		Yes

*The patient had no JIA-related symptom, but a CRP level of 35 mg/dL and generalized pain. According to the rheumatologists’ experience of this particular patients’ clinical history, the patient was regarded to be in an active disease phase
Abbreviations: CRP, C-reactive protein; MTX, Methotrexate; NA, data of CRP level was unavailable; NS, no clinical symptom; NT, no treatment ongoing

ISSN: 1546-0096