Fig. 2

Comparative analyses of protein levels in active sJIA, inactive sJIA and matched-healthy controls. Volcano plot of biomarkers between (A) active sJIA and healthy controls, and (D) inactive sJIA and healthy controls. Dots with colors (blue representing lower levels in patients and red representing higher levels in patients as compared with controls) are significantly different between the compared groups (p < 0.05). B and E Summary of the significantly different proteins in the two comparison pairs. C and F Heat maps show correlation between disease-associated protein levels among sJIA patients. Statistics: A, B, D and E Two-way ANOVA with correction of multiple comparison by controlling the False Discovery Rate (FDR) of 5% via two-stage step-up method of Benjamini, Krieger and Yekutieli. C and F) Spearman correlation, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001