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Table 3 Treatment protocols of these 18 CNO patients

From: Clinical characteristics and outcomes of chronic nonbacterial osteomyelitis in children: a multicenter case series

 

NSAIDs

DMARDs

Steriod

TNFi

BPs

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Case 1

  

Treated with NSAIDs, SASP and steroids. Followed 18 months. Remission on medication.

Case 2

     

Treated with antibiotic for 2 weeks and completely responsed. Then the patient was followed 2 years and confirmed self-limited.

Case 3

    

Followed 6 months. The patient was treated with alendronate for 4 months, and achieved resonse. But relapsed after withdrawl by himself for 1 months. Then treated with alendronate again.

Case 4

   

Followed only 1 month. Remission on medications.

Case 5

    

Followed 5 months. Remission on medications.

Case 6

 

Treated with antibiotics and NSAIDs and steroids for 2 weeks with no response. Then added MTX and TNFi with full response. Followed 30 months, only treated with TNFi now.

Case 7

 

 

Treated with NSAIDs for 2 month with no response, then added steriods and alendronate with full response. Followed 10 months, with remission on medications.

Case 8

  

Treated with NSAIDs for 2 months with no response, then added steriods and MTX with full response. Followed 29 months, with remisssion on medications.

Case 9

   

Treated with NSAIDs for 3 years with partial response, then treated with alendronate with full resonse. Followed 4 years and 6 months, with remission on medications.

Case 10

 

 

Treated with NSAIDs for 2 weeks with no response, then added steriods and TNFi with full response. Followed 3 months with remission on medications.

Case 11

  

Treaed with NSAIDs, thalidomide and steriods with full response. Followed 2 years with complete remission.

Case 12

 

  

Lost to follow up.

Case 13

 

 

Treaed with NSAIDs and MTX and TNFi with full response. But relapsed after withdrawl by himself. Then treated with NSAIDs and MTX and TNFi again. Followed 11 months with remission on medications.

Case 14

  

Treated with NSAIDs for 6 months with partial response. Then added MTX and Pamidophosphate with partial response. Then treated with NSAIDs and MTX and Pamidophosphate and TNFi with full response. Followed 10 months with remission on medications.

Case 15

 

Treated with NSAIDs and MTX for 2 months with partial response, then added pamidophosphate and TNFi with full response. Followed 10 months with remission on medications.

Case 16

Treated with NSAIDs and pamidophosphate with full response. But relapse after 6 months, then added MTX and steriods with no response, then added TNFi with full response. Followed 2 years, with remission on medications.

Case 17

   

Followed only 2 months.

Case 18

  

Treated with NSAIDs, MTX and pamidophosphate for 3 months with partial response.