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Table 1 Overview of published PAN patients treated with tocilizumab

From: A young girl with severe polyarteritis nodosa successfully treated with tocilizumab: a case report

Reference Age/Sex Symptoms CRP (mg/l) Previous treatment
TCZ treatment
Outcome
Inoue [8] 8y/F cPAN, fever, nodules, arthritis 100 GC, AZA, cyclo, MMF, tacrolimus, IVIG, anti-TNF
TCZ 8 mg/kg q2 wks IV
GC stopped
Remission (FU 7 mo)
Watanabe [9] 3y/M Fever, periostitis, arthritis, myositis, epididymo-orchitis 200 GC, IVIG, IFX
TCZ 10 mg/kg q4 wks + CYC
GC tapering
Improvement (FU 6 mo)
Krusche [10] 23y/M Livedo racemosa, myalgias, fever, weight loss, sensorimotor polyneuropathy, sc nodules 291 GC, MTX, RTX, CYC, ANR, IVIG
TCZ 8 mg/kg q4 wks IV + IVIG + GC, later TCZ 10 mg/kg q4 wks IV
Low dose GC
Remission (FU 37mo)
Krusche [10] 24y/M Myalgias, fever, weight loss, arthritis, sc nodules, drop hand, abdominal and flank pain, aHT, increased creatinine (1.3 mg/dl) 298 GC, IVIG, CYC
TCZ 8 mg/kg q4 wks IV + urbasone IV, later TCZ 162 mg weekly SC
Low dose GC
Remission (FU 11mo)
Krusche [10] 63y/F Myalgias, fever, fatigue, weight loss 174 GC
TCZ 162 mg weekly SC + GC, later TCZ 162 mg weekly SC
Low dose GC
Remission (FU 6mo)
Krusche [10] 70y/F Myalgias, arthritis, livedo racemosa, sensorimotor polyneuropathy 93 GC, MTX
TCZ 8 mg/kg q4 wks IV + GC, later TCZ 8 mg/kg q4 wks IV
Low dose GC
Mild livedo racemosa, otherwise asymptomatic (FU 13mo)
Saunier [11] 39y/F Necrotic purpura, myalgia, weight loss 59–126 GC, MTX, MMF, CYC, IFX, AZA
TCZ 8 mg/kg q4 wks IV
Low dose GC
Remission (FU 12mo)
Saunier [11] 52y/F Necrotic purpura, livedo, ulcerations, myalgia, arthritis, neuropathy, weight loss   GC, DAP, COL, MTX, CYC, AZA
TCZ 8 mg/kg q4 wks IV
Low dose GC
Remission (FU 12mo)
Saunier [11] 35y/M Arthritis, myalgia, tenosynovitis, nodules, weight loss 393 GC, IVIG
TCZ 8 mg/kg q4 wks IV
GC stopped
Remission (FU 10mo)
Hocevar [12] 33y/M Ulcers, aHT, myalgia, weight loss, nodules 169 GC, CYC
TCZ 8 mg/kg q4 wks IV
GC tapering
Improvement (FU 50mo)
Bodoki [13] 67y/M Fatigue, weight loss, myalgia, arthralgia, polyneuropathy 20 GC, CYC
TCZ 162 mg weekly IV
Low dose GC
Remission (FU 12mo)
  1. aHT Arterial hypertension. ANR Anakinra. AZA Azathioprine. COL Colchicine. cPAN Cutaneous polyarteritis nodosa. CYC Cyclophosphamide. Cyclo Cyclosporine. DAP Dapsone. F Female. FU Follow-up. GC Glucocorticoids. IFX Infliximab. IV Intravenous. IVIG Intravenous immunoglobulins. M Male. MMF Mycophenolate mofetil. MTX Methotrexate. RTX Rituximab. SC Subcutaneous. TCZ Tocilizumab. Q4 weekly every 4 weeks. Y Years