Table 1 Overview of published PAN patients treated with tocilizumab
From: A young girl with severe polyarteritis nodosa successfully treated with tocilizumab: a case report
Reference | Age/Sex | Symptoms | CRP (mg/l) | Previous treatment TCZ treatment | Outcome |
|---|---|---|---|---|---|
Inoue [8] | 8y/F | cPAN, fever, nodules, arthritis | 100 | GC, AZA, cyclo, MMF, tacrolimus, IVIG, anti-TNF TCZ 8 mg/kg q2 wks IV | GC stopped Remission (FU 7 mo) |
Watanabe [9] | 3y/M | Fever, periostitis, arthritis, myositis, epididymo-orchitis | 200 | GC, IVIG, IFX TCZ 10 mg/kg q4 wks + CYC | GC tapering Improvement (FU 6 mo) |
Krusche [10] | 23y/M | Livedo racemosa, myalgias, fever, weight loss, sensorimotor polyneuropathy, sc nodules | 291 | GC, MTX, RTX, CYC, ANR, IVIG TCZ 8 mg/kg q4 wks IV + IVIG + GC, later TCZ 10 mg/kg q4 wks IV | Low dose GC Remission (FU 37mo) |
Krusche [10] | 24y/M | Myalgias, fever, weight loss, arthritis, sc nodules, drop hand, abdominal and flank pain, aHT, increased creatinine (1.3 mg/dl) | 298 | GC, IVIG, CYC TCZ 8 mg/kg q4 wks IV + urbasone IV, later TCZ 162 mg weekly SC | Low dose GC Remission (FU 11mo) |
Krusche [10] | 63y/F | Myalgias, fever, fatigue, weight loss | 174 | GC TCZ 162 mg weekly SC + GC, later TCZ 162 mg weekly SC | Low dose GC Remission (FU 6mo) |
Krusche [10] | 70y/F | Myalgias, arthritis, livedo racemosa, sensorimotor polyneuropathy | 93 | GC, MTX TCZ 8 mg/kg q4 wks IV + GC, later TCZ 8 mg/kg q4 wks IV | Low dose GC Mild livedo racemosa, otherwise asymptomatic (FU 13mo) |
Saunier [11] | 39y/F | Necrotic purpura, myalgia, weight loss | 59–126 | GC, MTX, MMF, CYC, IFX, AZA TCZ 8 mg/kg q4 wks IV | Low dose GC Remission (FU 12mo) |
Saunier [11] | 52y/F | Necrotic purpura, livedo, ulcerations, myalgia, arthritis, neuropathy, weight loss | GC, DAP, COL, MTX, CYC, AZA TCZ 8 mg/kg q4 wks IV | Low dose GC Remission (FU 12mo) | |
Saunier [11] | 35y/M | Arthritis, myalgia, tenosynovitis, nodules, weight loss | 393 | GC, IVIG TCZ 8 mg/kg q4 wks IV | GC stopped Remission (FU 10mo) |
Hocevar [12] | 33y/M | Ulcers, aHT, myalgia, weight loss, nodules | 169 | GC, CYC TCZ 8 mg/kg q4 wks IV | GC tapering Improvement (FU 50mo) |
Bodoki [13] | 67y/M | Fatigue, weight loss, myalgia, arthralgia, polyneuropathy | 20 | GC, CYC TCZ 162 mg weekly IV | Low dose GC Remission (FU 12mo) |