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Table 4 Treatment effects

From: Changes over time in inflammatory and structural lesions at the sacroiliac joint in children with spondyloarthritis exposed and unexposed to tumor necrosis factor inhibitor

  N Average treatment effect (95% CI) p-value
SIS
 All 42 −7.85 (− 12.22, −3.49) 0.00
 Baseline SIS≥2* 21 − 14.50 (− 21.62, − 7.37) 0.00
 Baseline SIS< 2 21 − 1.27 (− 4.37, 1.83) 0.42
SSS
 Erosion 18 0.72 (−1.88, 3.31) 0.588
 Sclerosis 18 −0.18 (− 0.93, 0.56) 0.628
  1. Legend. Average treatment effects from TNFi use, adjusting for baseline SIS or SSS lesions scores as appropriate. Exposure defined as ≥90 days of TNFi use. *SPARCC SIS score ≥ 2 is used as a surrogate for MRI-sacroiliitis positive in clinical trials [23]