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Table 2 Unadjusted inflammation change scores

From: Changes over time in inflammatory and structural lesions at the sacroiliac joint in children with spondyloarthritis exposed and unexposed to tumor necrosis factor inhibitor

  All subjects TNFi exposed TNFi unexposed  
  Median SIS Change Score (IQR) p-value
All subjects 0.0 (−14.7, 0.0) [N = 45] −5.2 (−24.7, 0.0) [N = 22] 0.0 (− 10.3, 4.0) [N = 23] 0.09
Baseline SIS≥2* −16.8 (−26.0, − 10.3) [N = 22] −20.7 (−26.0, − 11.0) [N = 13] −14.3 (−20.2, −9.3) [N = 9] 0.09
Baseline SIS = 0 0.0 (0.0, 4.0) [N = 23] 0.0 (0.0, 0.0) [N = 9] 0.0 (0.0, 4.0) [N = 14] 0.12
  Frequency meeting MCID (%) p-value
All subjects 19 (42.22%) [N = 45] 11 (50.00%) [N = 22] 8 (34.78%) [N = 23] 0.30
Baseline SIS> 0 19 (86.36%) [N = 22] 11 (84.62%) [N = 13] 8 (88.89%) [N = 9] 0.77
  1. Legend. MRI sequence availability dictated which subjects were evaluated with SIS and SSS detailed scoring. Of the 46 unique subjects, one was missing the necessary sequences to perform SIS detailed scoring. *SPARCC SIS score ≥ 2 is used as a surrogate for MRI-sacroiliitis positive in clinical trials [23]