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Table 2 Unadjusted inflammation change scores

From: Changes over time in inflammatory and structural lesions at the sacroiliac joint in children with spondyloarthritis exposed and unexposed to tumor necrosis factor inhibitor

 

All subjects

TNFi exposed

TNFi unexposed

 
 

Median SIS Change Score (IQR)

p-value

All subjects

0.0 (−14.7, 0.0) [N = 45]

−5.2 (−24.7, 0.0) [N = 22]

0.0 (− 10.3, 4.0) [N = 23]

0.09

Baseline SIS≥2*

−16.8 (−26.0, − 10.3) [N = 22]

−20.7 (−26.0, − 11.0) [N = 13]

−14.3 (−20.2, −9.3) [N = 9]

0.09

Baseline SIS = 0

0.0 (0.0, 4.0) [N = 23]

0.0 (0.0, 0.0) [N = 9]

0.0 (0.0, 4.0) [N = 14]

0.12

 

Frequency meeting MCID (%)

p-value

All subjects

19 (42.22%) [N = 45]

11 (50.00%) [N = 22]

8 (34.78%) [N = 23]

0.30

Baseline SIS> 0

19 (86.36%) [N = 22]

11 (84.62%) [N = 13]

8 (88.89%) [N = 9]

0.77

  1. Legend. MRI sequence availability dictated which subjects were evaluated with SIS and SSS detailed scoring. Of the 46 unique subjects, one was missing the necessary sequences to perform SIS detailed scoring. *SPARCC SIS score ≥ 2 is used as a surrogate for MRI-sacroiliitis positive in clinical trials [23]
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Pediatric Rheumatology

ISSN: 1546-0096