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Table 1 Characteristics of studies included

From: Economic impact of Juvenile Idiopathic Arthritis: a systematic review

Article Country Currency
(Year)
Design N Follow-upa Total costs Direct costs Indirect costs
Reported Adjustedb Reported Adjustedb Reported Adjustedb
Angelis, 2016 [7] United Kingdom EUR (2012) Economic study 23 12 31,546 44,832 22,831 32,446 8,715 12,385
Bernatsky, 2007 [23] Canada CAD
(2005)
Retrospective observational 155 24    3,002 3,298   
Ens, 2013 [4] Canada CAD
(2009)
Cohort 54 12 1,063 1,122 708 748 355 375
Minden, 2004 [17] Germany EUR (1999) Economic study 215 12 3,471 5,591 1,899 3,059 1,571 2,530
Haapasaari, 2004 [26]cd Finland USD (2000) Cohort 31 12 7,732 11,753 7,339 11,155 418 635
Hughes, 2018 [14]de United Kingdom GBP (2016) Economic study 126 18 15,980 23,117     
Yucel, 2012 [27] Turkey EUR
(2009)
Cohort 100 12 3,994 6,844 3,913 6,705 81 139
Kuhlmann, 2016 [1] Germany, Italy, Spain, France, United Kingdom, Bulgaria, and Sweden EUR
(2012)
Economic study 162 12f 30,034 42,682     
Mars, 2019 [25] Finland EUR
(2014)
Retrospective observational 119 106    3,631 5,450   
Mars, 2019 [24] Finland EUR
(2014)
Retrospective observational 137 106    3,155 4,736   
Marshall, 2019 [28]g United States of America USD
(2016)
Cohort 3,815 12    10,175 10,830   
Minden, 2009 [18] Germany EUR
(2018)
Economic study 369 12 4,663 5,312 4,172 4,752   
Prince, 2011 [19]d Netherlands EUR
(2005)
Economic study 49 39    12,478 15,949   
Shenoi, 2018 [20]h France,
Germany, Netherlands, United Kingdom, and United States of America
USD
(2016)
Economic study 61 12 1,130 1,204 969 1,033   
Thornton, 2008 [22] United Kingdom GBP (2008) Economic study 276 12    1,649 2,709   
Khatun, 2021 [15] India INR
(2018)
Economic study 60 12 19,463 310 12,133 193 7,350 117
Kip, 2020 [16]i Netherlands EUR
(2019)
Economic study 691 120    2,103 2,436   
Thakral, 2020 [21]j United States of America USD
(2014)
Economic study 97 48    3,929 4,243   
  1. CAD Canada dollar, USD United States dollar, EUR Euro, GBP Great Britain pound, INR Indian rupee
  2. aExpressed in months
  3. bAdjusted to inflation and converted to US Dollar. Based on exchange rate on December 31, 2019
  4. cThis article reports quarterly costs
  5. dAfter biologic therapy
  6. eThis article reports costs on a period of 18 months
  7. fExtrapolated from a 6-month period
  8. gOnly JIA related Costs
  9. hOnly Systemic JIA
  10. iThis article reports only costs related to medication
  11. jOnly Oligoarticular JIA