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Table 1 (abstract P50). See text for description

From: Proceedings of the 27th European Paediatric Rheumatology Congress (PReS 2021)

 

Patient 1

Patient 2

RF/anti – CCP / ANA

(-) / (-) / (-)

(+) /(+) /(+)

Rheumatoid nodules / morning stiffness

(-) / (+)

(+)/ (+)

Anti- TNF a

Etanercept (4 months)

Adalinumab (2 years)

Adalinumab (9 years)

Neurological symptoms

right facial palsy

Romberg right

Left optic neuritis

 Anti- MOG / Anti- AQP4

(-) / (-)

(-) / (-)

 Oligoclonal bands

type 3

type 2

 MRI lesions of the brain – focal high intensity white matter lesions

in cerebral hemispheres & brain stem

in optic nerves & next to the lateral ventricles

 MRI lesions of the spinal cord without enhancement

at the cervical level C2 and thoracic level T6, T11- T12

at the cervical level C5

Autoimmune medical history

ENA (-)

ENA (-)

Anti- TPO (+)

Anti-TG (+)

Family medical history of RA

paternal aunt

grand mother

  1. ANA antinuclear antibodies, RF rheumatoid factor, RA rheumatoid arthritis
  2. Anti-CCP anti-cyclic citrullinated peptide, ENA extranuclear antibodies
  3. Anti-TPO anti thyroid peroxidase antibodies, Anti-TG anti thyroglobulin antibodies
  4. Anti-MOG anti-myelin oligodendrocyte glycoprotein, Anti-AQP4 anti-aquaporin 4