From: Proceedings of the 27th European Paediatric Rheumatology Congress (PReS 2021)
Phenotypic marker | Brief description | Expression on oJIA synovial fluid B cells (n=18) (median, interquartile range) | Expression on oJIA peripheral blood B cells (n=17) (median, interquartile range) | Result of Mann-Whitney U test |
---|---|---|---|---|
CD86 | Activation marker involved in antigen presentation | 33.4% (21.7%-46.3%) positive expression | 10.0% (6.9%-14.2%) positive expression | p<0.0001 U=3 |
HLA-DR | Activation marker involved in antigen presentation | 4096 (3347-4927) median fluorescent intensity | 1874 (1738-2074) median fluorescent intensity | p<0.0001 U=16 |
CD11c | Activation marker | 59.3% (46.0%-68.9%) positive expression | 20.0% (15.1%-25.2%) positive expression | p<0.0001 U=6 |
FcRL4 | Atypical marker expressed on pro-arthritogenic B cells in rheumatoid arthritis (1) | 20.0% (13.7%-46.3%) positive expression | 13.4% (10.3%-18.0%) positive expression | p=0.0240 U=85 |