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Fig. 1 | Pediatric Rheumatology

Fig. 1

From: Comment on: homozygous variant p. Arg90His in NCF1 is associated with early-onset interferonopathy: a case report

Fig. 1

Representation of the phosphate binding pocket of NCF1 p47phox domain with the electrostatic molecular surface. “A” for the native structure an “B” for the Arg90His mutant. The electrostatic surface is shown in color varying from blue (positive) to red (negative). Protein structural elements involved are shown as ribbons, Arg90 and His90 as sticks with the rest of the side chains as lines. The phosphate is shown in space fill representation. The electrostatic surface potential of the models was calculated by the Adaptive Poisson-Boltzmann Solver (APBS) using the PyMOL plug-in with the default parameter settings. The molecular graphics program PyMOL [9] was used to analyze the changes caused by the mutation and the molecular surface charge distribution and to display the results

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