Table 1 Baseline characteristics of initiators and non-initiators of first-line biologic therapy
Initiators (n = 71) | Non-initiators (n = 397) | p-value | |
|---|---|---|---|
Demographics | |||
Age, median (IQR) | 7.0 (4.0, 11.0) | 6.0 (3.0, 12.0) | 0.34 |
Sex (male), N (%) | 41 (57.7%) | 203 (51.1%) | 0.30 |
Race, N(%) | 0.66 | ||
White | 43 (60.6%) | 265 (66.8%) | |
Black | 12 (16.9%) | 49 (12.3%) | |
Asian | 3 (4.2%) | 12 (3.0%) | |
Other | 13 (18.3%) | 71 (17.9%) | |
Commercial insurance, N(%) | 163 (41.1%) | 33 (46.5%) | 0.39 |
Hospital Characteristics | |||
Hospital region, N(%) | 0.83 | ||
Northeast | 15 (21.1%) | 71 (17.9%) | |
Southeast | 13 (18.3%) | 69 (17.4%) | |
Southwest | 10 (14.1%) | 44 (11.1%) | |
Midwest | 18 (25.4%) | 120 (30.2%) | |
West | 15 (21.1%) | 93 (23.4%) | |
Hospital volume, N(%) | < 0.01 | ||
Low volume (≤ 12,000) | 3 (4.2%) | 39 (9.8%) | |
Medium low volume (12,000-15,999) | 5 (7.0%) | 88 (22.2%) | |
Medium high volume (16,000-21,000) | 28 (39.4%) | 131 (33.0%) | |
High volume (≥21,000) | 35 (49.3%) | 139 (35.0%) | |
Clinical Features Prior to Treatment Assignment | |||
Disease Severity Indicatorsa | |||
ICU level of care | 5 (7.0%) | 15 (3.8%) | 0.21 |
Multiple complete blood counts | 10 (14.1%) | 26 (6.5%) | 0.03 |
Blood gas | 6 (8.5%) | 17 (4.3%) | 0.13 |
Supplemental oxygen | 3 (4.2%) | 16 (4.0%) | 0.94 |