From: Intravenous administration of anakinra in children with macrophage activation syndrome
Patient | Age | Sex | Diagnosis | Anakinra dose (mg/kg/d) Initial Max | Duration (Days) | Triglycerides (mg/dl) baseline | Ferritin (ng/dl) Pre-Post | AST (U/L) Pre-Post | Fibrinogen (mg/dl) Pre-Post | Platelets (1000/UL) Pre post | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 1 | M | SJIA | 4 | 7.2 | 3 | 109 | 4667 | 2132 | 53 | 52 | 504 | 253 | 568 | 505 |
2 | 3 | F | SJIA | 7.4 | 7.4 | 11 | 160 | 130,000 | 3486 | 164 | 45 | 168 | 202 | 46 | 70 |
3 | 4 | M | SJIA | 7.8 | 15.4 | 5 | 102 | 8663 | 1097 | 766 | 160 | 81 | 170 | 84 | 173 |
4 | 6 | M | SJIA | 20 | 20 | 12 | Not done | 10,437 | 137 | 168 | 24 | 196 | 126 | 211 | 265 |
5 | 8 | F | SJIA | 8 | 8 | 3 | 83 | 5160 | 1954 | 74 | 472 | 426 | 392 | 343 | 591 |
6 | 13 | F | SJIA | 3.3 | 7.5 | 10 | 197 | 21,442 | 1442 | 935 | 42 | 83 | 152 | 113 | 267 |
7 | 13 | F | SJIA | 11 | 11 | 8 | 249 | 55,000 | 3933 | 325 | 107 | 118 | 91 | 120 | 311 |
8 | 16 | M | SJIA | 9.4 | 9.4 | 5 | 207 | 2016 | 294 | 16 | 13 | 637 | 509 | 471 | 429 |
9 | 16 | M | SJIA | 6 | 6 | 2 | 176 | 17,033 | 3850 | 125 | 120 | 221 | 221 | 180 | 243 |
10** | 20 | F | SJIA | 1.7 | 6.8 | 5 | 152 | 84,000 | 10 | 1812 | 314 | 170 | 319 | 23 | 81 |
11 | 16 | F | Lupus | 2.5 | 8 | 47 | 268 | 12,098 | 412 | 432 | 6 | 323 | 214 | 139 | 150 |
12 | 16 | M | Lupus | 6.6 | 6.6 | 10 | 165 | 5195 | 557 | 361 | 40 | 362 | 607 | 134 | 287 |
13 | 20 | M | Lupus | 10 | 10 | 85 | 782 | 120,000 | 1421 | 2521 | 23 | 190 | 158 | 239 | 188 |
14** | 13 | M | Vasculitis | 7.1 | 14.2 | 54 | 203 | 3186 | 12,398 | 46 | 128 | 321 | 779 | 22 | 42 |
15 | 3 | F | sHLH | 4 | 20 | 16 | 333 | 110,000 | 1240 | 66 | 28 | 335 | 155 | 298 | 290 |
16 | 9 | M | sHLH | 3 | 11 | 13 | 209 | 15,750 | 7855 | 41 | 42 | 295 | 405 | 709 | 174 |
17** | 10 | F | sHLH | 4 | 8 | 2 | 2617 | 1216 | 15,577 | 270 | 394 | 674 | 489 | 19 | 99 |
18** | 12 | F | sHLH | 2.2 | 4.2 | 9 | 336 | 92,000 | 67,000 | 265 | 26 | 375 | 595 | 12 | 101 |
19** | 19 | F | sHLH | 8 | 8 | 20 | 272 | 13,756 | 8004 | 166 | 134 | 376 | 205 | 60 | 56 |