Table 2 Histoplasmosis presentation. Data were collected for histoplasmosis infection, type, hospitalization, diagnostic tests, treatment, and outcomes
Pt | Known Exposure | Histoplasmosis Type | Histology Staining | Antigen (Serum, Urine) | Category | Days Hospitalized (Intensive care) | Antifungal Therapy | Outcome (months to HC or still antigen +) Itraconazole prophylaxis (months) | Months Follow Up After Histoplasmosis Diagnosis, Clearance |
|---|---|---|---|---|---|---|---|---|---|
1 JIA | No | PH | ND | +,+ | Probable | 18 | Amphotericin B Itraconazole | HC at 36.7 Prophylaxis for 19.6 | 80, 43.3 |
2 JIA | No | DH | + BAL | +,+ | Proven | 11 | Amphotericin B Itraconazole | HC at 37.2 Prophylaxis for 5.0 | 89, 51.8 |
3 JIA | No | DH | + pulmonary wedge biopsy | +,+ | Proven | 22, (14, ventilation) | Amphotericin B Itraconazole | HC at 12.7 Prophylaxis for 70.0 | 83, 70.3 |
4 cSLE | No | Uncategorized | ND | -,- | Possible | No | Itraconazole* | HC at 3.7 | 33, 29.3 |
5 JIA | No | PH | ND | -,- | Probable | No | Itraconazole Fluconazole | HC at 2.3 | 28, 25.7 |
6 JIA | Lives on farm | DH | ND | +,+ | Probable | 17 | Amphotericin B Itraconazole | HC at 21.2 Prophylaxis for 27.5 | 67, 45.8 |
7 JIA | Attended Bonfire | DH | ND | +,+ | Probable | 6 | Itraconazole | Asymptomatic Antigen < LOQ at 18.0+ Halted itraconazole 18.0 FHD | 26, NA |
8 MCTD | No | DH | ND | +,+ | Probable | 8 (1**, No ventilation) | Amphotericin B Itraconazole | Asymptomatic Antigen decreasing at 11.0 | 11, NA |
9 JIA | Birds and Bats in attic | PH | + pulmonary wedge biopsy | -,- | Proven | No | Itraconazole | HC at 3.3 | 18, 14.7 |
Summary: Median (range) | 33 % Yes 66 % No | 56 % DH 33 % PD 11 % unnoted | 3 Positive 6 ND | 67 % Antigen + (100 % DH, 33 % PH) | 3 Proven 5 Probable 1 Possible | 67 % for 14 (6–22) 11 % needing ventilation | *89 % Itraconazole 56 % Amphotericin B 11 % Fluconazole | 78 % now HC 12.7 to HC (2.3–37.2) 44 % prophylaxis for 23.6 (5–70) | FHD 33 (11-88.5) HC 29.3 (0-70.3) |