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Table 2 Response to treatment and coronary artery complications in children with Kawasaki disease

From: The occurrence of coronary artery lesions in Kawasaki disease based on C-reactive protein levels: a retrospective cohort study

Outcomes Total
n (%)
Low CRP < 3 mg/dL
(n = 2107), n (%)
High CRP ≥ 3 mg/dL
(n = 7024), n (%)
p-value
Spontaneous remission 341 (3.7)   174 (8.3)   167 (2.4) < 0.001
1st IVIG 8778 (96.1)   1929 (91.6)   6849 (97.5) < 0.001
Unresponsive to 1st IVIG 1602/8778 (18.3)   225 (11.7)   1377 (20.1) < 0.001
2nd IVIG 1435/1602 (89.6)   198 (88.0)   1237 (89.8) 0.453
Unresponsive to 2nd IVIG 342/1435 (23.8)   40 (20.2)   302 (24.4) 0.209
Acute CAL
 z-score 1271/9000 (14.1) 2082 380 (18.3) 6918 891 (12.9) < 0.001
 Japanese criteria 946/9014 (10.5) 2084 260 (12.5) 6930 686 (9.9) 0.001
Acute giant CAA
 z-score 56/9014 (0.6) 2084 13 (0.6) 6930 43 (0.6) 1.0
 Japanese criteria 13/9110 (0.1) 2101 3 (0.1) 7009 10 (0.1) 1.0
Convalescent CAL
 z-score 501/8196 (6.1) 1873 160 (8.5) 6323 341 (5.4) < 0.001
 Japanese criteria 419/8203 (5.1) 1875 127 (6.8) 6328 292 (4.6) < 0.001
Convalescent giant CAA
 z-score 28/8204 (0.3) 1875 1 (0.1) 6329 27 (0.4) 0.011
 Japanese criteria 8/8661 (0.1) 1971 0 6690 8 (0.1) 0.212
  1. KD Kawasaki Disease, CRP C-reactive protein, IVIG Intravenous immunoglobulin treatment, CAL Coronary artery lesion, CAA Coronary artery aneurysm; Japanese criteria, criteria of the Japanese Ministry of Ministry of Health and Welfare