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Table 1 Clinical characteristics between patients with low and high C-reactive protein levels among patient with KD

From: The occurrence of coronary artery lesions in Kawasaki disease based on C-reactive protein levels: a retrospective cohort study

Characteristics Total Low CRP < 3 mg/dL High CRP ≥ 3 mg/dL p-value
n Value n Value
N (%) 9131 2107 23.1 7024 76.9  
Age, months (mean ± SD) 9131 2107 31.7 ± 24.8 7024 34.4 ± 24.9 < 0.001
Male, n (%) 9053 2081 1261 (60.6) 6972 4042 (58.0) 0.033
Weight, kg (mean ± SD) 9131 2107 13.8 ± 6.0 7024 14.2 ± 5.9 0.003
Height, cm (mean ± SD) 9131 2107 90.2 ± 17.4 7024 92.2 ± 17.3 < 0.001
Fever, total days (mean ± SD) 8810 2027 6.3 ± 2.5 6783 6.6 ± 2.2 < 0.001
Fever, pretreatment, days (mean ± SD) 9025 2072 5.2 ± 2.1 6998 5.1 ± 1.7 0.206
Symptoms, n (%)
 Conjunctival injection 9010 2054 1664 (81.0) 6956 6220 (89.4) < 0.001
 Oral changes 9001 2050 1604 (78.2) 6951 5865 (84.4) < 0.001
 Extremity changes 8918 2028 1247 (61.5) 6890 4651 (67.5) < 0.001
 Rash 8984 2053 1484 (72.3) 6931 5349 (77.2) < 0.001
 BCG site redness 8354 1914 769 (40.2) 6440 2520 (39.1) 0.424
 Cervical lymphadenopathy 8960 2047 1015 (49.6) 6913 4179 (60.5) < 0.001
 Incomplete presentation, n (%) 8914 2006 844 (42.1) 6908 2187 (31.7) < 0.001
 Family history, n (%) 6543 1414 24 (1.7) 5129 68 (1.3) 0.312
 Recurrence, n (%) 8781 2017 99 (4.9) 6763 337 (5.0) 0.953
Laboratory results
 WBC, /mm3 (mean ± SD) 9126 2106 11.988 ± 4.881 7020 14.818 ± 5.163 < 0.001
 Neutrophil, % (mean ± SD) 9037 2066 52.2 ± 16.9 6971 66.5 ± 14.6 < 0.001
 Hemoglobin, g/dL (mean ± SD) 9096 2100 11.6 ± 0.97 6996 11.3 ± 1.02 < 0.001
 Platelets, × 103 (mean ± SD) 9105 2103 357.4 ± 126.8 7002 356.5 ± 109.8 0.765
 Platelets, ×10 [3], highest (mean ± SD) 8651 2002 422.6 ± 147.0 6649 483.6 ± 165.4 < 0.001
 Albumin, g/dL (mean ± SD) 9093 2093 4.0 ± 0.3 7000 3.8 ± 0.4 < 0.001
 AST, IU/L (mean ± SD) 9105 2100 64.6 ± 125.9 7005 94.0 ± 173.5 < 0.001
 ALT, IU/L (mean ± SD) 9095 2096 59.8 ± 131.5 6999 100.1 ± 149.3 < 0.001
 Total bilirubin, mg/dL (mean ± SD) 8978 2070 0.4 ± 0.47 6908 0.68 ± 0.83 < 0.001
 Na, mEq/L (mean ± SD) 8983 2059 137.0 ± 2.4 6924 136.2 ± 2.7 < 0.001
 CRP, mg/dL (mean ± SD) 9131 2107 1.59 ± 0.86 7024 9.20 ± 5.49 < 0.001
 ESR, mm/hr. (mean ± SD) 8356 1919 41.5 ± 24.9 6437 60.7 ± 26.7 < 0.001
 BNP, pg/mL (mean ± SD) 2079 519 55.3 ± 94.0 1559 199.4 ± 597.3 < 0.001
 ProBNP, pg/mL (mean ± SD) 5533 1266 551.5 ± 1081.5 4267 1624.2 ± 3400.8 < 0.001
 Pyuria, n (%) 9008 2076 409 (19.7) 6932 2652 (38.3) < 0.001
  1. KD Kawasaki Disease, CRP C-reactive protein, BCG Bacillus Calmette–Guérin, WBC White blood cell, AST Aspartate aminotransferase, ALT Alanine aminotransferase, BNP B-type natriuretic peptide, SD Standard deviation