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Table 3 Statistics correlation (p-value) between genetic variants and CIHs and clinical signs of Fabry disease significant p < 0.05

From: Frequency of Fabry disease in a juvenile idiopathic arthritis cohort

Symptoms c.1000-22C > T c.370-81_-77del c.640–16 A > G c.-10 C > T c1244 T > C c.38 C > T Hap1 Hap2 Hap3
AlfaGal Abn. 0.624 1.000 1.000 0.429 0.073 0.927 1.000 1.000 1.000
GB3 Abn 1.000 0.501 0.501 0.240 0.036 0.964 0.448 0.448 1.000
Heat Intolerance 0.012 0.022 0.022 0.116 0.091 0.091 0.098 0.098 0.325
fatigue 0.756 1.000 1.000 0.531 0.236 0.764 0.719 0.719 1.000
Tinnitus 0.202 1.000 1.000 0.531 0.236 0.764 0.719 0.719 0.234
Dysacusis 0.643 1.000 1.000 0.492 0.909 1.000 1.000 1.000 0.325
Acroparesthesias 0.278 0.775 0.775 0.437 1.000 0.473 0.764 0.764 0.613
Hyperhidrosis 0.222 0.102 0.102 0.624 0.273 0.273 0.493 0.493 1.000
Abdominal Dist 0.745 0.730 0.730 0.519 0.218 0.782 1.000 1.000 1.000
Dyspepsia 1.000 0.478 0.478 0.571 0.200 0.800 0.709 0.709 1.000
Diarrhea 0.718 0.212 0.212 0.733 0.145 0.145 0.405 0.405 1.000
Weight Gain Diff 0.775 0.213 0.213 0.024 0.309 0.691 0.322 0.322 1.000
Angiokeratoma 0.436 0.291 0.291 0.127 0.018 0.982 0.255 0.255 1.000
Valvar Abn 0.132 0.419 0.419 0.308 0.186 0.814 0.217 0.217 0.031
Arrhythmias 1.000 0.602 0.602 0.465 1.000 0.907 0.572 0.572 1.000
Visual Changes 0.073 0.046 0.046 0.005 0.213 0.787 0.01 0.01 0.521
Corneal Changes 0.002 0.003 0.003 0.012 0.255 0.401 0.05 0.05 1.000
Cornea Vertic 0.070 0.208 0.208 0,292 0.064 0.064 1.000 1.000 0.183
Cataract 0.426 1.000 1.000 0.894 1.000 0.979 1.000 1.000 0.064
Ant. Chamb Ch 0.004 0.006 0.006 0.011 1.000 0.128 0.164 0.164 0.343
Stroke FH 0.184 0.565 0.565 0.645 0.436 0.436 0.756 0.756 0.307
Trans. attack FH 0.186 0.081 0.081 0.240 0.036 0.001 0.448 0.448 1.000
Sudden death FH 1.000 0.346 0.346 0.586 0.327 0.673 0.510 0.510 1.000
kidney failure FH 0.686 0.660 0.660 0.423 1.000 0.891 1.000 1.000 0.379
Fabry FH 0.436 0.291 0.291 0.127 0.018 0.982 0.255 0.255 1.000
  1. Legend: Hap 1 = c.-10C > T, c.370-77_-81del, c.640-16A > G, c.1000-22C > T, Hap 2- c.370-77_-81del, c.640-16A > G, c.1000-22C > T, Hap 3 = c.548-125C > G, c.1000-22C > T, c.-12G > A. Abn: abnormal, Dist Distention, Diff difficulty, cornea Vertic cornea verticillata, Ant. Chamb Ch Anterior chamber changes,, FH Family history