Table 3 Statistics correlation (p-value) between genetic variants and CIHs and clinical signs of Fabry disease significant p < 0.05
From: Frequency of Fabry disease in a juvenile idiopathic arthritis cohort
Symptoms | c.1000-22C > T | c.370-81_-77del | c.640–16 A > G | c.-10 C > T | c1244 T > C | c.38 C > T | Hap1 | Hap2 | Hap3 |
|---|---|---|---|---|---|---|---|---|---|
AlfaGal Abn. | 0.624 | 1.000 | 1.000 | 0.429 | 0.073 | 0.927 | 1.000 | 1.000 | 1.000 |
GB3 Abn | 1.000 | 0.501 | 0.501 | 0.240 | 0.036 | 0.964 | 0.448 | 0.448 | 1.000 |
Heat Intolerance | 0.012 | 0.022 | 0.022 | 0.116 | 0.091 | 0.091 | 0.098 | 0.098 | 0.325 |
fatigue | 0.756 | 1.000 | 1.000 | 0.531 | 0.236 | 0.764 | 0.719 | 0.719 | 1.000 |
Tinnitus | 0.202 | 1.000 | 1.000 | 0.531 | 0.236 | 0.764 | 0.719 | 0.719 | 0.234 |
Dysacusis | 0.643 | 1.000 | 1.000 | 0.492 | 0.909 | 1.000 | 1.000 | 1.000 | 0.325 |
Acroparesthesias | 0.278 | 0.775 | 0.775 | 0.437 | 1.000 | 0.473 | 0.764 | 0.764 | 0.613 |
Hyperhidrosis | 0.222 | 0.102 | 0.102 | 0.624 | 0.273 | 0.273 | 0.493 | 0.493 | 1.000 |
Abdominal Dist | 0.745 | 0.730 | 0.730 | 0.519 | 0.218 | 0.782 | 1.000 | 1.000 | 1.000 |
Dyspepsia | 1.000 | 0.478 | 0.478 | 0.571 | 0.200 | 0.800 | 0.709 | 0.709 | 1.000 |
Diarrhea | 0.718 | 0.212 | 0.212 | 0.733 | 0.145 | 0.145 | 0.405 | 0.405 | 1.000 |
Weight Gain Diff | 0.775 | 0.213 | 0.213 | 0.024 | 0.309 | 0.691 | 0.322 | 0.322 | 1.000 |
Angiokeratoma | 0.436 | 0.291 | 0.291 | 0.127 | 0.018 | 0.982 | 0.255 | 0.255 | 1.000 |
Valvar Abn | 0.132 | 0.419 | 0.419 | 0.308 | 0.186 | 0.814 | 0.217 | 0.217 | 0.031 |
Arrhythmias | 1.000 | 0.602 | 0.602 | 0.465 | 1.000 | 0.907 | 0.572 | 0.572 | 1.000 |
Visual Changes | 0.073 | 0.046 | 0.046 | 0.005 | 0.213 | 0.787 | 0.01 | 0.01 | 0.521 |
Corneal Changes | 0.002 | 0.003 | 0.003 | 0.012 | 0.255 | 0.401 | 0.05 | 0.05 | 1.000 |
Cornea Vertic | 0.070 | 0.208 | 0.208 | 0,292 | 0.064 | 0.064 | 1.000 | 1.000 | 0.183 |
Cataract | 0.426 | 1.000 | 1.000 | 0.894 | 1.000 | 0.979 | 1.000 | 1.000 | 0.064 |
Ant. Chamb Ch | 0.004 | 0.006 | 0.006 | 0.011 | 1.000 | 0.128 | 0.164 | 0.164 | 0.343 |
Stroke FH | 0.184 | 0.565 | 0.565 | 0.645 | 0.436 | 0.436 | 0.756 | 0.756 | 0.307 |
Trans. attack FH | 0.186 | 0.081 | 0.081 | 0.240 | 0.036 | 0.001 | 0.448 | 0.448 | 1.000 |
Sudden death FH | 1.000 | 0.346 | 0.346 | 0.586 | 0.327 | 0.673 | 0.510 | 0.510 | 1.000 |
kidney failure FH | 0.686 | 0.660 | 0.660 | 0.423 | 1.000 | 0.891 | 1.000 | 1.000 | 0.379 |
Fabry FH | 0.436 | 0.291 | 0.291 | 0.127 | 0.018 | 0.982 | 0.255 | 0.255 | 1.000 |