Fig. 1
PCoA analyses of microbial community composition in fecal samples from children with JIA. The samples are clustered in the PCoA plots based on similarities in bacterial composition. Squares represent samples from treatment-naĂ¯ve children and circles represent samples from children during treatment with MTX or ETN. a. PCoA plot for 45 treatment-naĂ¯ve children and 29 children treated with MTX. b. PCoA plot for 45 treatment-naĂ¯ve children and 12 children treated with ETN. c. PCoA plot for paired analyses of 15 children sampled both when treatment-naĂ¯ve and later during treatment with MTX. The figures for each individual child have the same color for both the sample collected when treatment-naĂ¯ve and the sample collected during treatment with MTX. d. PCoA plot for paired analyses of 7 children sampled both when treatment-naĂ¯ve and later during treatment with ETN. The figures for each individual child have the same color for both the sample collected when treatment-naĂ¯ve and the sample collected during treatment with ETN. JIA = juvenile idiopathic arthritis, PCoA = principal coordinates analysis, MTX = methotrexate, ETN = etanercept, ANOSIM = analysis of similarity