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Table 4 Single nucleotide polymorphisms in association with the phenotype “MTX-nausea”

From: Single nucleotide polymorphisms associated with methotrexate-induced nausea in juvenile idiopathic arthritis

  Gene SNP Alleles, Major > minor MTX-nausea1 Allel count Controls Allel count OR (95% CI) p Chr. Genomic Position Consequence
Hepatic ABCC2 rs2273697 G > A 32 9 1.35 (0.64–2.84) 0.44 10 99,804,058 Missense
Efflux ABCC2 rs37400662 G > A 43 16 1.05 (0.48–2.30) 0.90 10 99,844,450 Missense
Transporter ABCC2 rs717620 G > A 24 9 1.00 (0.43–2.34) 1.00 10 99,782,821 5’UTR variant
ABCB1 rs2032582 G > T 45 17 0.99 (0.46–2.10) 0.94 7 87,531,302 Missense
G > A 3 2 0.54 (0.08–3.47) 0.51
ABCB1 rs1045642 T > C 50 19 0.97 (0.44–2.14) 0.94 7 87,509,329 Synonymous
Hepatic SLCO1B1 rs4149056 T > C 18 6 1.16 (0.41–3.31) 0.78 12 21,178,615 Missense
Influx SLCO1B1 rs4149081 G > A 19 7 1.02 (0.37–2.80) 0.96 12 21,225,087 Intron variant
Transporter SLCO1B3 rs2117032 T > C 43 14 1.20 (0.61–2.39) 0.60 12 20,921,188 Down stream 3’UTR
SLC19A1 rs10512662 G > A 48 18 1.04 (0.49–2.18) 0.93 21 45,537,880 Missense
Nausea HTR3A rs1062613 C > T 21 5 1.82 (0.60–5.47) 0.29 11 113,975,284 5’UTR variant
Receptor HTR3A rs1985242 T > A 36 9 1.85 (0.76–4.50) 0.17 11 113,977,551 5’UTR variant
HTR3A rs1176713 T > C 25 5 2.03 (0.73–5.60) 0.17 11 113,989,703 Synonymous
HTR3B rs1176744 T > G 37 14 0.99 (0.46–2.12) 0.97 11 113,932,306 Missense
MTHFR MTHFR rs18011312 A > C 41 13 1.30 (0.62–2.71) 0.49 1 11,794,419 Missense
Enzyme MTHFR rs1801133 C > T 34 12 1.10 (0.49–2.45) 0.82 1 11,796,321 Missense
  1. The additive effect of the minor allele on child-assessed MTX-induced nausea – the nausea diary. Listed for every single nucleotide polymorphism (SNP) are the respective gene, the alleles, the relevant chromosome (Chr.), the genomic position, and the consequence of the SNP
  2. N = 77, the patients who had completed at least seven diary entries
  3. OR Odds Ratio
  4. 1The “MTX-nausea” subgroup: children with a nausea diary illustrating a nausea pattern timely related to the MTX administration (n = 56). Controls (n = 21)
  5. 2SNP variant not available for one child