Gene | SNP | Alleles, Major > minor | MTX-nausea1 Allel count | Controls Allel count | OR (95% CI) | p | Chr. | Genomic Position | Consequence | |
---|---|---|---|---|---|---|---|---|---|---|
Hepatic | ABCC2 | rs2273697 | G > A | 32 | 9 | 1.35 (0.64–2.84) | 0.44 | 10 | 99,804,058 | Missense |
Efflux | ABCC2 | rs37400662 | G > A | 43 | 16 | 1.05 (0.48–2.30) | 0.90 | 10 | 99,844,450 | Missense |
Transporter | ABCC2 | rs717620 | G > A | 24 | 9 | 1.00 (0.43–2.34) | 1.00 | 10 | 99,782,821 | 5’UTR variant |
ABCB1 | rs2032582 | G > T | 45 | 17 | 0.99 (0.46–2.10) | 0.94 | 7 | 87,531,302 | Missense | |
G > A | 3 | 2 | 0.54 (0.08–3.47) | 0.51 | ||||||
ABCB1 | rs1045642 | T > C | 50 | 19 | 0.97 (0.44–2.14) | 0.94 | 7 | 87,509,329 | Synonymous | |
Hepatic | SLCO1B1 | rs4149056 | T > C | 18 | 6 | 1.16 (0.41–3.31) | 0.78 | 12 | 21,178,615 | Missense |
Influx | SLCO1B1 | rs4149081 | G > A | 19 | 7 | 1.02 (0.37–2.80) | 0.96 | 12 | 21,225,087 | Intron variant |
Transporter | SLCO1B3 | rs2117032 | T > C | 43 | 14 | 1.20 (0.61–2.39) | 0.60 | 12 | 20,921,188 | Down stream 3’UTR |
SLC19A1 | rs10512662 | G > A | 48 | 18 | 1.04 (0.49–2.18) | 0.93 | 21 | 45,537,880 | Missense | |
Nausea | HTR3A | rs1062613 | C > T | 21 | 5 | 1.82 (0.60–5.47) | 0.29 | 11 | 113,975,284 | 5’UTR variant |
Receptor | HTR3A | rs1985242 | T > A | 36 | 9 | 1.85 (0.76–4.50) | 0.17 | 11 | 113,977,551 | 5’UTR variant |
HTR3A | rs1176713 | T > C | 25 | 5 | 2.03 (0.73–5.60) | 0.17 | 11 | 113,989,703 | Synonymous | |
HTR3B | rs1176744 | T > G | 37 | 14 | 0.99 (0.46–2.12) | 0.97 | 11 | 113,932,306 | Missense | |
MTHFR | MTHFR | rs18011312 | A > C | 41 | 13 | 1.30 (0.62–2.71) | 0.49 | 1 | 11,794,419 | Missense |
Enzyme | MTHFR | rs1801133 | C > T | 34 | 12 | 1.10 (0.49–2.45) | 0.82 | 1 | 11,796,321 | Missense |