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Table 2 Genotypes for the selected single nucleotide polymorphisms

From: Single nucleotide polymorphisms associated with methotrexate-induced nausea in juvenile idiopathic arthritis

Gene SNP Ancestral Allel Genotypes Total, n MTX intolerant1 MTX tolerant p-value MTX Nausea2 Controls p-value
ABCC2 rs2273697 G GG 74 44 29 χ2 = 0.05 32 14 0.81
GA 32 20 12 p = 0.98 16 5
AA 13 8 5   8 2
ABCC2 rs37400663 G GG 38 23 15 0.74 19 7 1.00
GA 65 38 27   29 12
AA 15 10 4   7 2
ABCC2 rs717620 G GG 73 47 26 0.64 35 13 1.00
GA 39 21 17   18 7
AA 7 4 3   3 1
ABCB1 rs2032582 G GG 38 23 15 0.28 18 6 0.95
GT 58 34 24   27 10
GA 2 0 2   1 1
TA 3 3 0   2 1
TT 18 12 5   8 3
ABCB1 rs1045642 C CC 18 9 9 χ2 = 1.34 8 4 0.82
CT 68 44 24 p = 0.51 34 11
TT 33 19 13   14 6
SLCO1B1 rs4149056 T TT 84 49 34 0.86 39 15 1.00
TC 32 21 11   16 6
CC 3 2 1   1 0
SLCO1B1 rs4149081 G GG 80 47 32 0.86 38 14 1.00
GA 36 23 13   17 7
AA 3 2 1   1 0
SLCO1B3 rs2117032 C CC 17 12 5 χ2 = 2.16 10 4 0.63
CT 53 28 24 p = 0.34 23 6
TT 49 32 17   23 11
SLC19A1 rs10512663 G GG 33 18 15 χ2 = 0.76 17 6 0.89
GA 66 42 24 p = 0.68 28 12
AA 19 11 7   10 3
HTR3A rs1062613 C CC 80 52 28 0.13 36 16 0.58
CT 37 20 16   19 5
TT 2 0 2   1 0
HTR3A rs1985242 A AA 7 3 4 0.23 4 1 0.34
AT 55 30 24   28 7
TT 57 39 18   24 13
HTR3A rs1176713 C CC 6 3 3 0.68 3 1 0.18
CT 37 21 16   19 3
TT 76 48 27   34 17
HTR3B rs1776744 T TT 50 30 20 0.09 24 10 0.58
TG 58 32 25   27 8
GG 11 10 1   5 3
MTHFR rs18011313 A AA 52 34 18 χ2 = 0.93 24 9 0.29
AC 53 30 22 p = 0.63 21 11
CC 13 7 6   10 1
MTHFR rs1801133 C CC 58 33 25 0.02 27 10 1.00
CT 51 29 21   24 10
TT 10 10 0   5 1
  1. The genotype distribution for the selected single nucleotide polymorphisms (SNPs) – including the distribution of genotypes within the phenotype subgroups defined by the methotrexate intolerance severity score and the nausea diary
  2. SNP; Single Nucleotide Polymorphism
  3. 1The MTXintolerant subgroup: children with a total score of the Methotrexate Intolerance Severity Score (MISS) ≥6 and at least 1 point in the anticipatory and/or associative and/or behavioral symptoms (n = 72). Otherwise categorised as MTXtolerant (n = 46)
  4. 2The “MTX-nausea” subgroup: children with a nausea diary illustrating a nausea pattern timely related to the MTX administration (n = 56). The remaining children grouped as “Controls” (n = 21)
  5. 3SNP variant not available for one child
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