Authors | Brinkman et al. | Abinum et al. | Silva et al. |
---|---|---|---|
Year of publication | 2007 | 2009 | 2017 |
Number of patients | 22 | 7 | 16 |
Location | Netherlands | UK | UK |
HLA donor | Autologous stem cell transplantation (with T cell depletion) | Autologous stem cell transplantation (with T cell depletion) | MUDb 9/16 MSD: 4/16 mMUD: 3/16 |
Age at HSCT (median) | 9.1 years (range 4.2 to 18.2 years) | 10.8 years (range 6 to 18 years) | 21.5 months (range, 5 months to 12 years) |
Follow up (median) | 70 months (range 13–135 months) | 80 months (range 60–96 months) | 29 months (range, 2.8–8 years) |
Deaths | 2d | 1e | 2f |
Complete clinical remission | 8/20 | 4/6 | 11/14 |
Partial responders | 7/20 | 0/6 | 1/14 |
Relapse of the disease | 5/20 | 2/6 | 1/14 |
Infections: | 19/22 | 4/7 | 10/16 |
Viralc (CMV, HSV, EBV, VZV, BK virus) | 25 | 6 | 10 |
Bacterial | 8 | NC | 3 |
Fungal | 2 | NC | 1 |
Allo/auto-immune complications | – | 1/6 | 4/14 |
GVHD (grade II-IV) | – | – | 3/16 |