Sustained remission after haploidentical bone marrow transplantation in a child with refractory systemic juvenile idiopathic arthritis

Table 2 Results and outcome depending on the type of transplantation^a

Authors	Brinkman et al.	Abinum et al.	Silva et al.
Year of publication	2007	2009	2017
Number of patients	22	7	16
Location	Netherlands	UK	UK
HLA donor	Autologous stem cell transplantation (with T cell depletion)	Autologous stem cell transplantation (with T cell depletion)	MUD^b 9/16 MSD: 4/16 mMUD: 3/16
Age at HSCT (median)	9.1 years (range 4.2 to 18.2 years)	10.8 years (range 6 to 18 years)	21.5 months (range, 5 months to 12 years)
Follow up (median)	70 months (range 13–135 months)	80 months (range 60–96 months)	29 months (range, 2.8–8 years)
Deaths	2^d	1^e	2^f
Complete clinical remission	8/20	4/6	11/14
Partial responders	7/20	0/6	1/14
Relapse of the disease	5/20	2/6	1/14
Infections:	19/22	4/7	10/16
Viral^c (CMV, HSV, EBV, VZV, BK virus)	25	6	10
Bacterial	8	NC	3
Fungal	2	NC	1
Allo/auto-immune complications	–	1/6	4/14
GVHD (grade II-IV)	–	–	3/16

^a Two other cases report of autologous hematopoietic stem cell transplantation
- Mistric et al. (Vntir Lek, 1999) which was a success
- Quartier.P et al. (Lancet, 1999), the child died from toxoplasma infection
^bMUD Matched Unrelated Donor, MSD Matched Sibling Donor, mMUD Mismatched Unrelated Donor
^c HSV herpes simplex virus, CMV cytomegalovirus, EBV Epstein-Barr virus, VZV Varicella zoster virus
^d Two children died from Macrophage Activation Syndrome (P1 at D + 18, P2 at D + 120)
^e One patient died 4 months post-transplant from disseminated adenovirus reactivation
^f One child died from invasive fungal infection and one from sepsis twenty months after HSCT

ISSN: 1546-0096