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Table 2 Results and outcome depending on the type of transplantationa

From: Sustained remission after haploidentical bone marrow transplantation in a child with refractory systemic juvenile idiopathic arthritis

Authors Brinkman et al. Abinum et al. Silva et al.
Year of publication 2007 2009 2017
Number of patients 22 7 16
Location Netherlands UK UK
HLA donor Autologous stem cell transplantation (with T cell depletion) Autologous stem cell transplantation (with T cell depletion) MUDb 9/16
MSD: 4/16
mMUD: 3/16
Age at HSCT (median) 9.1 years (range 4.2 to 18.2 years) 10.8 years (range 6 to 18 years) 21.5 months (range, 5 months to 12 years)
Follow up (median) 70 months (range 13–135 months) 80 months (range 60–96 months) 29 months (range, 2.8–8 years)
Deaths 2d 1e 2f
Complete clinical remission 8/20 4/6 11/14
Partial responders 7/20 0/6 1/14
Relapse of the disease 5/20 2/6 1/14
Infections: 19/22 4/7 10/16
Viralc (CMV, HSV, EBV, VZV, BK virus) 25 6 10
Bacterial 8 NC 3
Fungal 2 NC 1
Allo/auto-immune complications 1/6 4/14
GVHD (grade II-IV) 3/16
  1. a Two other cases report of autologous hematopoietic stem cell transplantation
  2. - Mistric et al. (Vntir Lek, 1999) which was a success
  3. - Quartier.P et al. (Lancet, 1999), the child died from toxoplasma infection
  4. bMUD Matched Unrelated Donor, MSD Matched Sibling Donor, mMUD Mismatched Unrelated Donor
  5. c HSV herpes simplex virus, CMV cytomegalovirus, EBV Epstein-Barr virus, VZV Varicella zoster virus
  6. d Two children died from Macrophage Activation Syndrome (P1 at D + 18, P2 at D + 120)
  7. e One patient died 4 months post-transplant from disseminated adenovirus reactivation
  8. f One child died from invasive fungal infection and one from sepsis twenty months after HSCT