Sustained remission after haploidentical bone marrow transplantation in a child with refractory systemic juvenile idiopathic arthritis

Table 1 Immune reconstitution after transplantation

Time after HSCT	M + 3	M + 4	M + 5	M + 6	M + 9	M + 12	M + 18	M + 24	M + 36	Normal values in healthy children
Age (years)	3.8	46	47	48	51	54	60	66	78	2 to 6
CD3⁺ (cells/ μl)	186	346	197	324	394	447	1249	3451	4635	1400–3700
CD4⁺ (cells/ μl) - CD31⁺ CD45RA⁺ naive (%) -CD45RO⁺ memory (%)	158	278	131	211	254	305 24 68	866	2090 62 32	2754	700–2200 43–55 58–70
CD8⁺ (cells/ μl)	20	56	36	68	79	81	262	1118	1411	490–1300
-CD45RA⁺CCR7⁺ naive (%)						55		41		52–68
-CD45RA⁻CCR7⁺ central memory (%)						11		1,5		3–4
-CD45RA⁻CCR7⁻ effector memory (%)						28		4,5		11–20
-CD45RA⁺CCR7⁻ TEMRA (%)						6,5		13		16–28
CD19⁺ (cells/ μl)	154	208	55	102	307	417	624	1312	1948	390–1400
CD16⁺ 56⁺ (cells/ μl)	57	125	102	125	149	132	121	49	134	130–720
T cell proliferations (cpm/min/10^3)
-PHA, J3								72		> 50

PHA phytohemagglutinin
The patient achieved a CD4⁺ count > 400/μl at M4. Naïve T cells appeared at M12. The percentage was 24% for CD4 ⁺CD31⁺CD45RA⁺ and 54% for CD8 ⁺CD45RA⁺CCR7⁺

ISSN: 1546-0096