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Table 1 Patient characteristics at baseline (start of methotrexate)

From: Outcome of children with oligoarticular juvenile idiopathic arthritis compared to polyarthritis on methotrexate- data of the German BIKER registry

  persistent oligoJIA extended oligoJIA RF negative polyarthritis
patients [n] 370 221 467
Female gender [n, %] 244 (66) 161 (73) 370 (79)
age at onset [years]
 mean, +/− SD 6.4 +/− 4.3 5.2 +/− 3.7 8.4 +/−  4.7
 median, (IQR) 5.0 (2.6; 9.75) 4.2 (2.2;7.4) 8.9 (4.03;12.4)
age at MTX start [years]
 mean, +/− SD 8.7 +/− 4.7 8.5 +/−  4.3 9.7 +/−  4.9
 median, (IQR) 8.1 (4.5;12.7) 8.6 (0.6;4.4) 10.3 (5.7;14)
disease duration [years]
 mean, +/− SD 2.4 +/− 2.9 3.2 +/− 3.7 1.3 +/−  2
 median, (IQR) 1.1 (0.5;3.1) 1.6 (0.64;4.41) 0.5 (0.26;1.44)
MTX starting dose [mg/m2]
 median, (IQR) 12.6 (11;14.1) 12.1 (10.5;13.8) 12.5 (10.9;14)
Pretreatment
 NSAR [n, %] 315 (85.1) 195 (88.2) 394 (84.4)
 i.a. Steroids [n, %] 186 (50.3) 85 (38.46) 100 (4.28)
concomitant treatment at enrolment, [n, %]
 oral steroids [n, %] 48 (13) 33 (15) 147 (32)
 steroids pulse therapy last 3 month [n, %] 6 (1.6) 3 (1.4) 20 (4.3)
 conventional DMARDs, [n, %] 9 (2.4) 9 (4.1) 10 (2.1)
ANA- positive [n, %] 216 (58.49) 146 (66.1) 240 (51.4)
Uveitis at enrolment [n, %] 49 (13.2) 27 (12.2) 9 (1.9)
Active arthritis at enrolement [n, %] 329 (88.9) 209 (94.6) 443 (94.9)
number of active joints
 mean +/−SD 2.1 +/− 1.8 4.1 +/− 4.1 11.1 +/− 10.3
 median (IQR) 3 (2; 20) 5 (3; 34) 15 (8; 55)
ESR > 20 mm/1 h [n, %] 128 (37.2) 83 (41.9) 197 (45.4)
CRP > 5 mg/l [n, %] 117 (33.7) 91 (45.0) 217 (48.5)
JADAS 10 mean, +/−SD [0–14]
median (IQR)
9.9 +/− 4.8
9.9 (6.3; 13.2)
11.8 +/− 4.9
11.8 (8.5; 15.2)
16.7 +/− 6.3
21.2 (17.0; 21.2)
  1. DMARD biologic disease-modifying antirheumatic drug, MTX methotrexate, ESR erythrocyte sedimentation rate, CRP C-reactive protein, JADAS juvenile Disease activity Score (JADAS 10, mean SD, median IQR), LOM limitation of motion, number of active joints (defined by the presence of swelling or, when absent, the limited range of motion accompanied by either pain or tenderness on motion)