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Table 3 Comparison of clinical data between the groups of repeated IVIG responders and non-responders in KD

From: Predictive value of C-reactive protein to albumin ratio as a biomarker for initial and repeated intravenous immunoglobulin resistance in a large cohort of Kawasaki disease patients: a prospective cohort study

  IVIG-responsive (n = 48) IVIG-resistance (n = 31) p value
Male 25 (52.1) 18 (58.1) 0.649
Age, months 28.0 (13.0–55.0) 29.0 (14.0–54.0) 0.885
BMI, kg/m2 15.0 (14.1–15.9) 15.3 (14.5–16.1) 0.539
Clinical manifestations
 Rash 40 (83.3) 30 (96.8) 0.141
 Extremity changes 26 (54.2) 15 (48.4) 0.651
 Conjunctivitis 43 (89.6) 28 (90.3) 1.000
 Oral changes 45 (93.8) 31 (100.0) 0.276
 Cervical lymphadenopathy 26 (54.2) 16 (51.6) 1.000
 Fever duration before initial IVIG, days 5.0 (5.0–7.0) 5.0 (5.0–6.0) 0.123
 Incomplete KD 17 (35.4) 8 (25.8) 0.461
 CALs 7 (14.6) 4 (12.9) 1.000
Before initial IVIG
 WBC, ×109/L 14.5 (11.0–17.5) 13.9 (9.0–20.1) 0.814
 Hemoglobin, g/L 109.0 (102.0–115.8) 104.0 (96.0–111.0) 0.161
 CRP, mg/L 79.0 (58.5–109.5) 122.0 (72.0–168.0) 0.006
 ESR, mm/h 67.0 (47.5–95.0) 67.0 (40.0–100.0) 0.917
 AST, U/L 35.0 (24.3–75.3) 34.0 (28.0–57.0) 0.204
 ALT, U/L 57.0 (23.0–133.0) 46.0 (34.0–92.0) 0.173
 ALB, g/L 37.0 (33.0–39.8) 33.0 (29.0–38.0) 0.010
 TBil, μmol/L 7.0 (5.0–13.0) 7.0 (4.0–42.0) 0.044
 Na+, mmol/L 136.0 (134.0–138.0) 134.0 (131.0–135.0) 0.007
 NLR 4.12 (2.93–7.66) 7.67 (2.52–12.27) 0.020
 PLR 136.8 (92.4–214.4) 146.4 (93.9–329.9) 0.052
 CAR 2.02 (1.62–3.16) 3.n (2.11–4.76) 0.002
  1. Abbreviations: ALB Albumin; AST Aspartate aminotransferase; ALT Alanine aminotransferase; BMI Body mass index; CRP C-reactive protein; CAR C-reactive protein-to-albumin ratio; CALs Coronary artery lesions; ESR Erythrocyte sedimentation rate; IVIG Intravenous immunoglobulin; KD Kawasaki disease; NLR Neutrophil-lymphocyte ratio; PLR Platelet-lymphocyte ratio; TBil Total bilirubin; Na+ Sodium; WBC White blood cell;
  2. The data are presented as the median with the 25th and 75th percentiles in square brackets for continuous variables and as the percentage for the categorical variables