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Table 1 Comparison of clinical data between the groups of initial IVIG-response and IVIG-resistance in KD

From: Predictive value of C-reactive protein to albumin ratio as a biomarker for initial and repeated intravenous immunoglobulin resistance in a large cohort of Kawasaki disease patients: a prospective cohort study

  IVIG-responsive (n = 471) IVIG-resistance (n = 79) p value
Male 271 (57.5) 43 (54.4) 0.625
Age, months 24.0 (13.0–42.0) 28.0 (14.0–54.0) 0.016
BMI, kg/m2 15.3 (14.5–16.0) 15.1 (14.3–16.2) 0.487
Clinical manifestations
 Rash 365 (77.5) 67 (84.8) 0.182
 Extremity changes 286 (60.7) 41 (51.9) 0.173
 Conjunctivitis 431 (91.5) 71 (89.9) 0.666
 Oral changes 599 (91.0) 99 (94.3) 0.347
 Cervical lymphadenopathy 193 (41.0) 42 (53.2) 0.049
 Fever duration before initial IVIG, days 5.0 (5.0–6.0) 5.0 (5.0–6.0) 0.313
 Incomplete KD 173 (36.7) 25 (31.6) 0.054
 CALs 41/463 (8.9) 11/79 (13.9) 0.153
Before initial IVIG
 WBC, ×109/L 13.3 (10.6–16.8) 14.3 (10.6–17.5) 0.718
 Hemoglobin, g/L 109.0 (101.0–116.0) 107.0 (99.0–114.0) 0.346
 CRP, mg/L 70.0 (41.0–106.0) 90.0 (62.0–144.0) 0.001
 ESR, mm/h 64.0 (46.0–81.0) 67.0 (47.0–96.0) 0.242
 AST, U/L 31.0 (25.0–48.0) 34.0 (25.0–65.0) 0.485
 ALT, U/L 35.0 (21.0–78.0) 53.0 (27.0–120.0) 0.085
 ALB, g/L 38.0 (35.0–41.0) 36.0 (32.0–39.0) <0.001
 TBil, μmol/L 6.0 (4.0–8.0) 7.0 (4.0–15.0) <0.001
 Na+, mmol/L 137.0 (135.0–139.0) 135.0 (133.0–137.0) <0.001
 NLR 2.63 (1.71–4.80) 4.83 (2.92–8.65) <0.001
 PLR 103.9 (74.8–151.1) 137.2 (93.9–235.0) <0.001
 CAR 1.86 (1.04–2.88) 2.60 (1.67–4.27) <0.001
  1. Abbreviations: ALB Albumin; AST Aspartate aminotransferase; ALT Alanine aminotransferase; BMI Body mass index; CRP C-reactive protein; CAR C-reactive protein-to-albumin ratio; CALs Coronary artery lesions; ESR Erythrocyte sedimentation rate; IVIG Intravenous immunoglobulin; KD Kawasaki disease; NLR Neutrophil-lymphocyte ratio; Na+ Sodium; PLR Platelet-lymphocyte ratio; TBil Total bilirubin; WBC White blood cell;
  2. The data are presented as the median with the 25th and 75th percentiles in square brackets for continuous variables and as the percentage for the categorical variables