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Table 1 Comparison of clinical data between the groups of initial IVIG-response and IVIG-resistance in KD

From: Predictive value of C-reactive protein to albumin ratio as a biomarker for initial and repeated intravenous immunoglobulin resistance in a large cohort of Kawasaki disease patients: a prospective cohort study

 

IVIG-responsive (n = 471)

IVIG-resistance (n = 79)

p value

Male

271 (57.5)

43 (54.4)

0.625

Age, months

24.0 (13.0–42.0)

28.0 (14.0–54.0)

0.016

BMI, kg/m2

15.3 (14.5–16.0)

15.1 (14.3–16.2)

0.487

Clinical manifestations

 Rash

365 (77.5)

67 (84.8)

0.182

 Extremity changes

286 (60.7)

41 (51.9)

0.173

 Conjunctivitis

431 (91.5)

71 (89.9)

0.666

 Oral changes

599 (91.0)

99 (94.3)

0.347

 Cervical lymphadenopathy

193 (41.0)

42 (53.2)

0.049

 Fever duration before initial IVIG, days

5.0 (5.0–6.0)

5.0 (5.0–6.0)

0.313

 Incomplete KD

173 (36.7)

25 (31.6)

0.054

 CALs

41/463 (8.9)

11/79 (13.9)

0.153

Before initial IVIG

 WBC, ×109/L

13.3 (10.6–16.8)

14.3 (10.6–17.5)

0.718

 Hemoglobin, g/L

109.0 (101.0–116.0)

107.0 (99.0–114.0)

0.346

 CRP, mg/L

70.0 (41.0–106.0)

90.0 (62.0–144.0)

0.001

 ESR, mm/h

64.0 (46.0–81.0)

67.0 (47.0–96.0)

0.242

 AST, U/L

31.0 (25.0–48.0)

34.0 (25.0–65.0)

0.485

 ALT, U/L

35.0 (21.0–78.0)

53.0 (27.0–120.0)

0.085

 ALB, g/L

38.0 (35.0–41.0)

36.0 (32.0–39.0)

<0.001

 TBil, μmol/L

6.0 (4.0–8.0)

7.0 (4.0–15.0)

<0.001

 Na+, mmol/L

137.0 (135.0–139.0)

135.0 (133.0–137.0)

<0.001

 NLR

2.63 (1.71–4.80)

4.83 (2.92–8.65)

<0.001

 PLR

103.9 (74.8–151.1)

137.2 (93.9–235.0)

<0.001

 CAR

1.86 (1.04–2.88)

2.60 (1.67–4.27)

<0.001

  1. Abbreviations: ALB Albumin; AST Aspartate aminotransferase; ALT Alanine aminotransferase; BMI Body mass index; CRP C-reactive protein; CAR C-reactive protein-to-albumin ratio; CALs Coronary artery lesions; ESR Erythrocyte sedimentation rate; IVIG Intravenous immunoglobulin; KD Kawasaki disease; NLR Neutrophil-lymphocyte ratio; Na+ Sodium; PLR Platelet-lymphocyte ratio; TBil Total bilirubin; WBC White blood cell;
  2. The data are presented as the median with the 25th and 75th percentiles in square brackets for continuous variables and as the percentage for the categorical variables