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Table 3 Multiple adjusted relationships between clinical risk factors and CIMT

From: Disease activity index is associated with subclinical atherosclerosis in childhood-onset systemic lupus erythematosus

Carotid intima-media thickness (CIMT) in mm
  Simple model Multiple model
Mo Variable MD p-value 95%CI MD p-value 95%CI
LL UL LL UL
1 SLEDAI 2 K > 5 −0.033 0.03 −0.064 −0.0029 −0.026 0.06 −0.054 0.001
2 SLEDAI 2 K > 5 −0.033 0.03 −0.064 −0.0029 −0.038 0.03 −0.073 −0.0029
3 SLEDAI 2 K > 5 − 0.033 0.03 − 0.064 − 0.0029 − 0.044 0.02 − 0.081 − 0.0065
4 Proteinuria 0.032 0.04 0.0017 0.06 0.017 0.24 −0.012 0.047
5 CrCla −0.045 0.07 −0.094 0.004 −0.023 0.41 −0.082 0.034
6 CrCla −0.045 0.07 −0,094 0.004 0.012 0.87 −0.14 0.16
7 Prot MS 0.011 0.52 −0,024 0.047 0.005 0.84 −0.045 0.055
8 Prot MS 0.011 0.52 −0,024 0.047 0.006 0.7 −0.026 0.039
  1. mm millimeters, CI confidence interval, SLEDAI 2 K Systemic Lupus Erythematosus Disease Activity Index. aCrCl - estimated creatinine clearance < 75 ml / min / 1.73 m2, Proteinuria- protein-creatinine ratio above 0.2; Prot MS -moderate to severe proteinuria; LL lower limit, UL upper limit, CI confidence interval, MD difference between the means
  2. Models 1, 4, 5, 8 adjusted by cumulative prednisone dose used and disease duration in months
  3. Model 2 adjusted by total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, low-density lipoprotein
  4. Models 3, 6, 7 adjusted by total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, low-density lipoprotein, presence of uncontrolled hypertension and short stature