Disease activity index is associated with subclinical atherosclerosis in childhood-onset systemic lupus erythematosus

Table 3 Multiple adjusted relationships between clinical risk factors and CIMT

Carotid intima-media thickness (CIMT) in mm
		Simple model				Multiple model
Mo	Variable	MD	p-value	95%CI		MD	p-value	95%CI
Mo	Variable	MD	p-value	LL	UL	MD	p-value	LL	UL
1	SLEDAI 2 K > 5	−0.033	0.03	−0.064	−0.0029	−0.026	0.06	−0.054	0.001
2	SLEDAI 2 K > 5	−0.033	0.03	−0.064	−0.0029	−0.038	0.03	−0.073	−0.0029
3	SLEDAI 2 K > 5	− 0.033	0.03	− 0.064	− 0.0029	− 0.044	0.02	− 0.081	− 0.0065
4	Proteinuria	0.032	0.04	0.0017	0.06	0.017	0.24	−0.012	0.047
5	CrCl^a	−0.045	0.07	−0.094	0.004	−0.023	0.41	−0.082	0.034
6	CrCl^a	−0.045	0.07	−0,094	0.004	0.012	0.87	−0.14	0.16
7	Prot MS	0.011	0.52	−0,024	0.047	0.005	0.84	−0.045	0.055
8	Prot MS	0.011	0.52	−0,024	0.047	0.006	0.7	−0.026	0.039

mm millimeters, CI confidence interval, SLEDAI 2 K Systemic Lupus Erythematosus Disease Activity Index. ^aCrCl - estimated creatinine clearance < 75 ml / min / 1.73 m2, Proteinuria- protein-creatinine ratio above 0.2; Prot MS -moderate to severe proteinuria; LL lower limit, UL upper limit, CI confidence interval, MD difference between the means
Models 1, 4, 5, 8 adjusted by cumulative prednisone dose used and disease duration in months
Model 2 adjusted by total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, low-density lipoprotein
Models 3, 6, 7 adjusted by total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, low-density lipoprotein, presence of uncontrolled hypertension and short stature

ISSN: 1546-0096