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Table 5 Adverse event rates during treatment with ANA and CANA

From: Experiences with IL-1 blockade in systemic juvenile idiopathic arthritis – data from the German AID-registry

  CANA ANA
sJIA sJIA
(n = 26 patients, PY = 56.4) (n = 80 patients, PY = 228)
Events; Rate per 100 PY (95% CI) Events; Rate per 100 PY (95% CI)
AE total 15; 26.6 (14.9; 43.9) 45; 19.7 (14.4; 26.4)
 Infections 6; 10.6 (3.9; 23.2) 15; 6.6 (3.7; 10.9)
 Headache 5; 8.9 (2.9; 20.7) 8; 3.5 (1.5; 6.9)
 Neutropenia 3; 5.3 (1.1; 15.5) 9; 3.9 (1.8; 7.5)
 Increase of transaminases 6; 10.6 (3.9; 23.2) 11; 4.8 (2.4; 8.6)
 Urticaria   2; 0.9 (0.1; 3.2)
 Hematuria   4; 1.8 (0.5; 4.5)
 Skin reaction   2; 0.9 (0.1; 3.2)
 Proteinuria 2; 3.5 (0.4; 12.8) 4; 1.8 (0.5; 4.5)
 Dizziness   
 Local site reaction/ aversion 1; 1.8 (0.0; 9.9) 5; 2.2 (0.7; 5.1)
 Nausea   1; 0.4 (0.0; 2.4)
 Leucopenia   1; 0.4 (0.0; 2.4)
 Thrombocytopenia 1; 1.8 (0.0; 9.9)  
 Stomach pain 1; 1.8 (0.0; 9.9)  
 Breast pain 1; 1.8 (0.0; 9.9)  
 Nocturnal sweating   1; 0.4 (0.0; 2.4)
 Acne   3; 1.3 (0.3; 3.8)
  1. PY Person Years