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Table 1 Patient characteristics and disease courses

From: Experiences with IL-1 blockade in systemic juvenile idiopathic arthritis – data from the German AID-registry

  ANA n = 84 CANA n = 27   ANA n = 80a CANA n = 26a
Age at diagnosis 5.5 years 7.4 years    
Symptoms before IL-1i    under IL-1i   
Fever 90% 85%   28% 27%
Skin involvement 71% 81%   25% 33%
- Joint involvement* (arthritis/arthralgia) 59 70% / 19 23% 23 85% / 16 59%   37 46% / 21 26% 11 41% / 5 19%
- Abdominal 30% 70%   13% 26%
- Serositis 17% 11%   4% 4%
Duration of initial therapy to IL-1i 15 months 15 months    
Age at start of IL-1i 6.8 years 8.7 years    
Duration of IL-1i 34 months 16 months    
Disease course
 MC 7 (8%) 0 (0%)    
 PC 36 (43%) 14 (52%)    
 PA 41 (49%) 13 (48%)    
Joint involvement* polyarthritis 41 (49%) 13 (48%)   25 (31%) 7 (27%)
oligoarthritis 18 (21%) 8 (30%)   12 (15%) 4 (15%)
arthralgia 19 (23%) 16 (59%)   21 (26%) 5 (19%)
none 6 (7%) 0 (0%)   22 (28%) 10 (38%)
  1. asymptoms unsatisfactory recorded
  2. (IL-1i IL-1 inhibition, MC monocyclic, PC polycyclic, PA polyarticular)
  3. *Specification of joint involvement