Severe fatigueb | ||||||||
---|---|---|---|---|---|---|---|---|
No. assessed | Fatiguea mean ±SD | No. (%) | OR (95% CI) crude | p-value | OR (95% CI) adjustedc | p-value | VAS fatigued mean ±SD | |
Norwegian controls | 109 | 2.8 ±1.1 | 13 (12) | 1.0 (ref.) | – | 1.0 (ref.) | – | 2.5 ±2.3 |
Total Nordic JIA cohort | 377 | 3.2 ±1.5 | 99 (26) | 2.6 (1.4–4.9) | 0.002 | 2.7 (1.4–5.1) | 0.002 | 3.8 ±2.7h |
Sleep qualitye | ||||||||
Good sleep, PSQI ≤5 | 213 | 2.7 ±1.2 | 32 (15) | 1.0 (ref.) | – | 1.0 (ref.) | – | 2.8 ±2.5 |
Poor sleep, PSQI > 5 | 158 | 3.9 ±1.4 | 66 (42) | 4.1 (2.5–6.6) | < 0.001 | 3.7 (2.2–6.1) | < 0.001 | 5.3 ±2.4 |
VAS pain | ||||||||
0 | 153 | 2.6 ±1.1 | 20 (13) | 1.0 (ref.) | – | 1.0 (ref.) | – | 2.9 ±2.6h |
> 0 | 217 | 3.7 ±1.5 | 79 (36) | 3.8 (2.2–6.6) | < 0.001 | 3.7 (2.1–6.5) | < 0.001 | 4.5 ±2.7 |
Participation in work/study | ||||||||
Full | 301 | 3.0 ±1.3 | 64 (21) | 1.0 (ref.) | – | 1.0 (ref.) | – | 3.6 ±2.6h |
Partial | 33 | 4.0 ±1.7 | 15 (45) | 3.1 (1.5–6.5) | 0.003 | 2.8 (1.3–6.0) | 0.008 | 4.1 ±2.9 |
No | 38 | 4.0 ±1.8 | 19 (50) | 3.7 (1.9–7.4) | < 0.001 | 3.5 (1.7–7.3) | 0.001 | 5.1 ±3.1 |
SF-36 | ||||||||
PCS ≥40 | 322 | 3.0 ±1.3 | 64 (20) | 1.0 (ref.) | – | 1.0 (ref.) | – | 3.4 ±2.6h |
PCS < 40 | 55 | 4.7 ±1.6 | 35 (64) | 7.1 (3.8–13.0) | < 0.001 | 6.2 (3.3–11.8) | < 0.001 | 6.2 ±2.4 |
MCS ≥40 | 310 | 2.9 ±1.3 | 58 (19) | 1.0 (ref.) | – | 1.0 (ref.) | – | 3.3 ±2.6h |
MCS < 40 | 67 | 4.6 ±1.5 | 41 (61) | 6.9 (3.9–12.1) | < 0.001 | 7.1 (3.9–13.0) | < 0.001 | 6.5 ±1.9 |
HAQ | ||||||||
=0 | 260 | 2.8 ±1.3 | 47 (18) | 1.0 (ref.) | – | 1.0 (ref.) | – | 3.2 ±2.5h |
> 0 | 110 | 4.1 ±1.6 | 52 (47) | 4.1 (2.5–6.6) | < 0.001 | 3.7 (2.2–6.1) | < 0.001 | 5.4 ±2.7 |
Disease statusf | ||||||||
Remission off med. | 112 | 2.9 ±1.4 | 21 (19) | 1.0 (ref.) | – | 1.0 (ref.) | – | 3.2 ±2.7h |
Inactive disease | 75 | 3.2 ±1.5 | 22 (29) | 1.8 (0.9–3.6) | 0.09 | 2.0 (1.0–4.1) | 0.06 | 3.7 ±2.7 |
Active disease | 121 | 3.6 ±1.6 | 43 (36) | 2.4 (1.3–4.4) | 0.005 | 2.2 (1.2–4.2) | 0.01 | 4.4 ±2.8 |
Not ascertainedg | 61 | 3.1 ±1.3 | 12 (20) | 1.0 (0.5–2.3) | 0.9 | 1.0 (0.4–2.2) | 1.0 | 4.3 ±2.5 |