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Table 2 Fatigue in the Nordic JIA cohort according to clinical characteristics at 18-year follow-up

From: Fatigue in young adults with juvenile idiopathic arthritis 18 years after disease onset: data from the prospective Nordic JIA cohort

   

Severe fatigueb

 

No. assessed

Fatiguea mean ±SD

No. (%)

OR (95% CI) crude

p-value

OR (95% CI) adjustedc

p-value

VAS fatigued mean ±SD

Norwegian controls

109

2.8 ±1.1

13 (12)

1.0 (ref.)

1.0 (ref.)

2.5 ±2.3

Total Nordic JIA cohort

377

3.2 ±1.5

99 (26)

2.6 (1.4–4.9)

0.002

2.7 (1.4–5.1)

0.002

3.8 ±2.7h

Sleep qualitye

 Good sleep, PSQI ≤5

213

2.7 ±1.2

32 (15)

1.0 (ref.)

1.0 (ref.)

2.8 ±2.5

 Poor sleep, PSQI > 5

158

3.9 ±1.4

66 (42)

4.1 (2.5–6.6)

< 0.001

3.7 (2.2–6.1)

< 0.001

5.3 ±2.4

VAS pain

 0

153

2.6 ±1.1

20 (13)

1.0 (ref.)

1.0 (ref.)

2.9 ±2.6h

 > 0

217

3.7 ±1.5

79 (36)

3.8 (2.2–6.6)

< 0.001

3.7 (2.1–6.5)

< 0.001

4.5 ±2.7

Participation in work/study

 Full

301

3.0 ±1.3

64 (21)

1.0 (ref.)

1.0 (ref.)

3.6 ±2.6h

 Partial

33

4.0 ±1.7

15 (45)

3.1 (1.5–6.5)

0.003

2.8 (1.3–6.0)

0.008

4.1 ±2.9

 No

38

4.0 ±1.8

19 (50)

3.7 (1.9–7.4)

< 0.001

3.5 (1.7–7.3)

0.001

5.1 ±3.1

SF-36

 PCS ≥40

322

3.0 ±1.3

64 (20)

1.0 (ref.)

1.0 (ref.)

3.4 ±2.6h

 PCS < 40

55

4.7 ±1.6

35 (64)

7.1 (3.8–13.0)

< 0.001

6.2 (3.3–11.8)

< 0.001

6.2 ±2.4

 MCS ≥40

310

2.9 ±1.3

58 (19)

1.0 (ref.)

1.0 (ref.)

3.3 ±2.6h

 MCS < 40

67

4.6 ±1.5

41 (61)

6.9 (3.9–12.1)

< 0.001

7.1 (3.9–13.0)

< 0.001

6.5 ±1.9

HAQ

 =0

260

2.8 ±1.3

47 (18)

1.0 (ref.)

1.0 (ref.)

3.2 ±2.5h

 > 0

110

4.1 ±1.6

52 (47)

4.1 (2.5–6.6)

< 0.001

3.7 (2.2–6.1)

< 0.001

5.4 ±2.7

Disease statusf

 Remission off med.

112

2.9 ±1.4

21 (19)

1.0 (ref.)

1.0 (ref.)

3.2 ±2.7h

 Inactive disease

75

3.2 ±1.5

22 (29)

1.8 (0.9–3.6)

0.09

2.0 (1.0–4.1)

0.06

3.7 ±2.7

 Active disease

121

3.6 ±1.6

43 (36)

2.4 (1.3–4.4)

0.005

2.2 (1.2–4.2)

0.01

4.4 ±2.8

 Not ascertainedg

61

3.1 ±1.3

12 (20)

1.0 (0.5–2.3)

0.9

1.0 (0.4–2.2)

1.0

4.3 ±2.5

  1. JIA juvenile idiopathic arthritis, No. numbers, SD standard deviation, OR odds ratio for Fatigue Severity Scale ≥4, CI confidence interval, ref. reference, VAS pain self-reported pain measured on a 21-numbered circle visual analogue scale (0 = no pain, 10 = maximum pain), SF-36 36-Item Short Form Health Survey, 0–100 (< 40 poor health), PCS physical component summary, MCS mental component summary, HAQ Health Assessment Questionnaire, 0–3 (0 = lowest, 3 = highest)
  2. aFatigue measured with Fatigue Severity Scale global score, 1–7 (1 = lowest, 7 = highest)
  3. bFatigue Severity Scale ≥4
  4. cAdjusted for age and sex
  5. dFatigue Severity Scale visual analogue scale, 21-numbered circle VAS (0 = no fatigue, 10 = maximum fatigue)
  6. eSleep quality measured with Pittsburgh Sleep Quality Index global score (PSQI), 0–21 (0 = best, 21 = worst)
  7. fAccording to the definition by Wallace et al.; Remission off med. = remission off medication for ≥12 months. Inactive disease = inactive disease on medication less than 6 months or inactive disease off medication less than 12 months or remission on medication (inactive disease on medication for more than 6 months). Active disease = flare or continuous active disease
  8. gNot ascertained = participated only in a telephone interview
  9. h1 of 377 participants did not fill in VAS fatigue