| | Total (n = 40) | Pediatric controls (n = 20) | JDM patients (n = 20) | p-value |
|---|
| Age (years) | 12.4 ± 4.1 | 12.7 ± 3.9 | 12.1 ± 4.4 | 0.651 |
| Female gender | 28 (70%) | 14 (70%) | 14 (70%) | > 0.999 |
| Race | | | | 0.392 |
| White, non-Hispanic | 14 (35%) | 5 (25%) | 9 (45%) | |
| Black, non-Hispanic | 8 (20%) | 4 (20%) | 4 (20%) | |
| Hispanic | 18 (45%) | 11 (55%) | 7 (35%) | |
| BMI | 20.9 ± 5 | 20.9 ± 4.9 | 21 ± 5.1 | 0.950 |
| BMI category | | | | > 0.999 |
| Healthy | 24 (60%) | 12 (60%) | 12 (60%) | |
| Overweight/Obese | 16 (40%) | 8 (40%) | 8 (40%) | |
| Positive cardiac family history | 23 (58%) | 12 (60%) | 11 (58%) | 0.894 |
| Systolic blood pressure (mmHg) | 109.8 ± 10.8 | 106.9 ± 10.5 | 112.8 ± 10.5 | 0.081 |
| Diastolic blood pressure (mmHg) | 66 ± 7 | 63.7 ± 6.9 | 68.4 ± 6.6 | 0.035 |
| Total cholesterol (mg/dL) | 159.1 ± 32.9 | 163.1 ± 29.1 | 154.8 ± 36.7 | 0.441 |
| LDL (mg/dL) | 87.6 ± 25.5 | 92.8 ± 23.5 | 82.3 ± 27.0 | 0.203 |
| HOMA-IRb | 2.1 [1.4, 3.1] | 2 [1.7, 2.8] | 2.1 [1.2, 3.3] | 0.922 |
| Hemoglobin A1c | 5.5 ± 0.3 | 5.6 ± 0.3 | 5.4 ± 0.3 | 0.084 |
| Lipoprotein A (nmol/L)c | 46 [14,87] | 66 [24,91] | 16.5 [10, 70] | 0.055 |
| Apolipoprotein B/A1 ratio | 0.5 ± 0.1 | 0.53 ± 0.1 | 0.46 ± 0.1 | 0.082 |
| hsCRP (mg/L) | 0.2 [0.1, 0.7] | 0.3 [0.2, 0.8] | 0.2 [0.1, 0.4] | 0.178 |
| RHI | 1.57 [1.2,1.9] | 1.43 [1.2, 1.7] | 1.72 [1.3, 2.4] | 0.148 |
| Abnormal RHI < 1.67 | 25 (63%) | 15 (75%) | 10 (50%) | 0.103 |
| Log RHI | 0.45 ± 0.33 | 0.36 ± 0.24 | 0.54 ± 0.39 | 0.089 |
- a Continuous variables expressed as mean ± standard deviation or median [interquartile range]. Categorical variables expressed as frequency (percentages)
- b Homeostatic Model Assessment for Insulin Resistance (HOMA-IR): HOMA-IR = fasting insulin x fasting glucose / 22.5 [43]
- c Only evaluated in 31 participants (17 pediatric controls and 14 JDM patients)
