Drug | Administration | Dose |
---|---|---|
Pamidronate (2nd generation) | Intravenous (dilute in 100-250 ml physiological saline solution, in 3–4 hours) | <  1 year: 0. 5 mg/kg every 2 months 1–2 years: 0. 25-0. 5 mg/kg/day 3 days every 3 months 2–3 years: 0.375–0.75 mg/kg/day 3 days every 3 months >  3 years: 0. 5–1 mg/kg/day 3 days every 4 months Maximum dose: 60 mg/dose and 11. 5 mg/kg/year |
Neridronate (3rd generation) | Intravenous (dilute in 200–250 ml physiological saline solution, in 3 hours) | 1–2 mg/kg/day every 3–4 months |
Zolendronate (3rd generation) | Intravenous (dilute in 50 ml physiological saline solution, in 30-45 min) | 0.0125–0.05 mg/kg every 6–12 months (maximum dose 4 mg) |
Alendronate (2nd generation) | Oral | 1–2 mg/kg/week <  40 kg: 5 mg/day or 35 mg/week >  40 kg: 10 mg/day or 70 mg/week Maximum dose: 70 mg/week |
Risendronate (3rd generation) | Oral | 15 mg/week (<  40 kg); 30 mg/week (> 40 kg) Maximum dose: 30 mg/week |