Fig. 3

TNF, IL-6 and MMP3 production (PB) in HC, SpA and ERA patients. Scatter plots representing TNF, IL-6 and MMP3 production in PB in three group of subjects, HC (25), SpA (50) and ERA (52) patients as measured via ELISA. Each dot represents an individual sample. Horizontal line represents median. WB diluted 1:1 with complete culture medium was used for assessing the pro-inflammatory cytokine production post stimulation with endogenous and exogenous ligands. TNF production in response to (a). No stimulation (b). LPS or PG stimulation (c). TNC or MRP8 stimulation. IL-6 production in response to (d). No stimulation. (e.) LPS or PG stimulation (f). TNC or MRP8 stimulation. MMP3 production in response to (g). No stimulation. (h.) LPS or PG stimulation (i). TNC or MRP8 stimulation. WB: whole blood, HC: healthy controls, SpA: Spondyloarthropathy, ERA: enthesitis related arthritis, Uns- unstimulated, LPS- Lipopolysaccaride, PG- peptidoglycan, TNC- Tenascin-C and MRP8-Myeloid related protein 8, TNF: tumor necrosis factor, IL-6: Interleukin-6, MMP3: Matrix metalloproteinase 3