TY - JOUR AU - DeCoste, Chelsea AU - Mateos-Corral, Dimas AU - Lang, Bianca PY - 2021 DA - 2021/01/06 TI - Shrinking lung syndrome treated with rituximab in pediatric systemic lupus erythematosus: a case report and review of the literature JO - Pediatric Rheumatology SP - 7 VL - 19 IS - 1 AB - Shrinking lung syndrome (SLS), a rare complication of systemic lupus erythematosus (SLE) characterized by dyspnea, low lung volumes, and a restrictive pattern on pulmonary function tests (PFTs), has only been reported in a few children. Given the rarity of SLS there is a paucity of literature regarding its optimal treatment. Outcomes are variable, with case reports documenting some improvement in most patients treated with corticosteroids, with or without additional immunosuppressive agents. However, most reported patients did not recover normal lung function. We report full recovery of a child with SLE and SLS following treatment with rituximab and review the current literature. SN - 1546-0096 UR - https://doi.org/10.1186/s12969-020-00491-0 DO - 10.1186/s12969-020-00491-0 ID - DeCoste2021 ER -