Fig. 6From: Type I interferonopathies with novel compound heterozygous TREX1 mutations in two siblings with different symptoms responded to tofacitinibEffects of the mutations in TREX1 in the patient were simulated by means of SWISS-MODEL. a Predicted normal TREX1 protein structure. b Predicted TREX1 protein structure with a specific missense mutation. c Predicted TREX1 protein structure with a specific frameshift mutationBack to article page