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Table 3 Factors associated with disease activity over time among prevalent cases of polyarticular JIA

From: Longitudinal assessment of racial disparities in juvenile idiopathic arthritis disease activity in a treat-to-target intervention

 

Unadjusted

Adjusted

β

[95% CI]

p-value

β

[95% CI]

p-value

Age at index visit

0.04

[− 0.09, 0.18]

0.52

  

Male sex

0.23

[−1.45, 1.91]

0.79

  

Race

 White

  

  

 Black

3.16

[1.00, 5.32]

< 0.01

1.16

[−0.12, 2.44]

0.08

 Asian/Other

−0.39

[−2.24, 1.46]

0.68

−0.40

[−1.45, 0.65]

0.46

 Hispanic ethnicity

−0.99

[−3.54, 1.55]

0.44

   

Public insurance

1.00

[−0.27, 2.26]

0.12

0.54

[−0.17, 1.25]

0.14

RF positivity

0.36

[−1.57, 2.29]

0.72

   

Baseline cJADAS-10

0.56

[0.49, 0.62]

< 0.01

0.54

[0.47, 0.61]

< 0.01

Non-biologic DMARD usea

−0.51

[−1.34, 0.32]

0.23

   

Biologic usea

−1.13

[−2.07, −0.18]

0.02

−0.43

[− 1.09, 0.23]

0.20

Time (months)

−0.15

[−0.24, − 0.07]

< 0.01

−0.13

[− 0.21, − 0.04]

< 0.01

Time-squared

0.004

[0.001, 0.01]

< 0.01

0.003

[0.001, 0.01]

0.01

  1. Marginal effect of covariates on repeated measures of cJADAS over time, estimated from linear mixed-effects models for prevalent cases of polyarticular JIA
  2. aTime-varying covariate
  3. RF rheumatoid factor; cJADAS-10 clinical Juvenile Arthritis Disease Activity Score; DMARD disease-modifying anti-rheumatic drug