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Fig. 9 | Pediatric Rheumatology

Fig. 9

From: Juvenile idiopathic arthritis fibroblast-like synoviocytes influence chondrocytes to alter BMP antagonist expression demonstrating an interaction between the two prominent cell types involved in endochondral bone formation

Fig. 9

Possible paradigms for the role of FLS in growth disturbances in JIA. JFLS in culture favor expression of genes related to BMP as opposed to TGFβ (a). In the presence of exogenous BMP4, JFLS show a decrease in BMP antagonists that have a high affinity for BMP4 which allows for these cells to differentiate further along chondrocyte lineage as demonstrated by an increase in COLX and ALP, late-stage markers, and a decrease in COL2, an early-stage marker (a). Cell hypertrophy is required for endochondral bone formation. Similar to JFLS in culture, chondrocytes cultured in JFLS-conditioned media favor expression of genes related to BMP as opposed to TGFβ (b). Unlike JFLS in culture, Ch-JFLS decrease protein expression of hypertrophic marker, COLX and have increased protein expression of BMP antagonist, chordin which can contribute to the inhibition of endochondral bone formation (b)

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Pediatric Rheumatology

ISSN: 1546-0096