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Fig. 8 | Pediatric Rheumatology

Fig. 8

From: Juvenile idiopathic arthritis fibroblast-like synoviocytes influence chondrocytes to alter BMP antagonist expression demonstrating an interaction between the two prominent cell types involved in endochondral bone formation

Fig. 8

Protein expression of collagen II (COL2), a marker of proliferating chondrocytes and collagen X (COLX), a marker of chondrocyte hypertrophy as determined by ELISA on cell media supernatants. While both Ch-CFLS and Ch-JFLS decrease expression of proliferation marker, COL2, the difference was only significant in Ch cultured in CFLS-conditioned media (a). Hypertrophic marker, COLX is significantly downregulated in both Ch-CFLS and Ch-JFLS (b) (p < 0.05, t-test)

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Pediatric Rheumatology

ISSN: 1546-0096