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Fig. 7 | Pediatric Rheumatology

Fig. 7

From: Juvenile idiopathic arthritis fibroblast-like synoviocytes influence chondrocytes to alter BMP antagonist expression demonstrating an interaction between the two prominent cell types involved in endochondral bone formation

Fig. 7

Protein expression of BMP antagonists: chordin, noggin, follistatin, and gremlin. Using ELISA to measure protein expression, both Ch-CFLS and Ch-JFLS significantly overexpress chordin when compared to untreated Ch with the greater difference seen in Ch cultured in JFLS-conditioned media (a) (p < 0.05) while noggin, follistatin, and gremlin remained unchanged (b, c, and d)

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Pediatric Rheumatology

ISSN: 1546-0096