Table 1 Laboratory studies. Patient laboratory values are displayed for the patient for the ranges from hospitalizations at our institution with the normal value ranges for each indicated test listed
From: Heme oxygenase-1 deficiency presenting with interstitial lung disease and hemophagocytic flares
Test | Normal Values | Patient’s Values |
|---|---|---|
Biochemical | ||
ALT | 5–41 IU/L | 165–615 |
AST | 6–40 IU/L | 44–157 |
GGT | 15–85 IU/L | 30–405 |
Total bilirubin | 0.0–1.1 mg/dL | 0.2 |
INR | < 1.0 | 1.2–1.6 |
Fibrinogen | 230–450 mg/dL | 57–493 |
D-dimer | ≤0.5 mg FEU/mL | > 20 |
Ceruloplasmin | 29–56 mg/dL | 48 |
Liver copper | 10–35 μg/g dry weight | 43 |
Plasma copper | 56–191 mcg/dL | 191 |
Triglycerides | 60–135 mg/dL | 95–503 |
LDL | < 110 mg/dL | 324 |
HDL | > 39 mg/dL | 58 |
Total LDH | 145–345 U/L | 5490–28,019 |
LDH 1 (%) | 17.5–28.3% (I, Heart) | 7.5–10 |
LDH 2 (%) | 30.4–36.4% (II) | 17.6–21 |
LDH 3 (%) | 19.2–24.8% (III) | 26.9 |
LDH 4 (%) | 9.6–15.6% (IV) | 23.7 |
LDH 5 (%) | 5.5–12.7% (V, Liver) | 24.3 |
Ferritin | 10–300 ng/mL | 555–4264 |
sIL-2R | 45–1105 U/mL | 145 |
Immunological | ||
IgG | 608–1572 mg/dL | 1050–1140 |
IgA | 52–242 mg/dL | 261 |
IgM | 45–236 mg/dL | 89–108 |
IgE | 0.98–570.6 mg/dL | 105 |
IgD | ≤10 mg/dL | 3 |
PPSV23 (PCV13) | ≥8/21 (≥5/12) | 8/21 (5/12) |
Tetanus | ≥0.01 IU/mL | 0.43 |
C3 | 83–203 mg/dL | 186 |
C4 | 16–52 mg/dL | 24 |
CH50 | > 32 unit/mL | 69 |
CD3 | 1200-2600/mm3 | 6086; 1465 |
CD4 | 650–1500/mm3 | 3793; 786 |
CD8 | 370–1100/mm3 | 2117; 661 |
CD4:CD8 | > 2:1 | 1:8:1; 1.2:1 |
CD16+CD56+ | 120–480/mm3 | 882; 89 |
CD19 | 270–860/mm3 | 1588; 232 |
PHA | > 30% | 24.70% |
anti-CD3 | > 30% | 21.50% |
NK function | ||
50:1 | > 20 | 11 |
25:1 | > 10 | 9 |
12.5:1 | > 5 | 5 |
6.25:1 | > 1 | 5 |
Lytic units | > 3.1 | 2.5 |