Fig. 2
From: Heme oxygenase-1 deficiency presenting with interstitial lung disease and hemophagocytic flares
Histopathology demonstrating unique features of HMOX1 deficiency. a Trichrome stained sections from lung biopsy tissue demonstrate extensive alveolar septal fibrosis and scattered granulomas. b Iron staining of lung tissue highlights hemosiderin laden macrophages (blue granules) associated with cholesterol granulomas. c Trichrome stained liver biopsy with mild sinusoidsal fibrosis and microvesicular steatosis and (d) iron stained liver biopsy with increased iron (blue granules) in Kupffer cells (blue). e Wright stained bone marrow aspirate demonstrating hemophagocytosis. f Peripheral blood smear demonstrating anisocytosis, schistocytes, elliptocytes, and a Howell-Jolly body