From: Bacterial infections in a pediatric cohort of primary and acquired complement deficiencies
Pt | Agea (yrs)/Sex | Comp Def | Laboratory results | Infections history (SBI, n) |
---|---|---|---|---|
1 | 3 / M | C2 | Undetectable CH50, ↓ C2 level and function; C1q, C1r, C1s levels normal | Pneumococcal pneumonia, E. coli bacteremia, otitis media; recurrent acute otitis media (SBI = 2) |
2 | 12 / M | C6 | Family history of C6 deficiency, undetectable CH50, ↓ C6 level; (C5, C7-C9 levels normal). | Neisseria meningitidis meningitis and bacteremia (SBI = 1) |
3 | 4 / M | C2 | Undetectable CH50, undetectable C2 level; (C1, C3- C9 levels normal) | Two episodes of Streptococcal bacteremia, one episode of streptococcal meningitis, recurrent sinusitis (SBI = 3) |
4 | 15 / M | C6 | Undetectable CH50, ↓ C6 level; (C3, C5, C7-C9 levels normal) | Neisseria meningitidis meningitis and bacteremia (SBI = 1) |
5 | 11 / M | C1q | Undetectable CH50, ↓ C1 level and function, ↓ C1q, (C1r, C1s, C2-C9 levels and function normal) | Streptococcal pneumoniae bacteremia and meningitis (SBI = 1) |
6 | 10 / F | C2 | Undetectable CH50, undetectable C2 level; (C3-C9 levels normal) | Neisseria meningitidis meningitis, recurrent otitis media (SBI = 1) |
7 | 21 / M | C8 | ↓ CH50, undetectable AH50, ↓ C8 level, (C2-C7, C9 levels, properdin level normal) | Two episodes of Neisseria meningitidis meningitis, recurrent otitis media (SBI = 2) |
8 | 6 / M | C1q | Undetectable CH50, ↓ C1q level; (AH50, C1r, C1s, C2, C4 levels normal) | Streptococcal bacteremia (SBI = 1) |
9b | 5 / M | C2 | Family history of C2 deficiency, undetectable CH50, ↓ C2 level | None (Sjogren’s syndrome) (SBI = 0) |
10b | 4 / F | C1q | Family history of C1 deficiency, undetectable CH50, low C1q level | None (Discoid lupus) (SBI = 0) |
11 | 3 / M | C2 | Undetectable CH50, ↓ C2 level and function | Group B streptococcal meningitis and bacteremia; Streptococcal pneumoniae bacteremia, otitis media (SBI = 2) |
12 | 18 / F | C6 | Family history of C6 deficiency, undetectable CH50 and AH50, undetectable C6 function | None (erythromelalgia) (SBI = 0) |
13 | 20 / F | C2 | Undetectable CH50, previous physician diagnosis. | Recurrent otitis media and sinusitis; recurrent UTI, pyelonephritis (SBI = 2) |
14 | 18 / M | C2 | Undetectable CH50, undetectable C2 level and function; (AH50, C1, C4 levels normal) | Recurrent otitis media and sinusitis; multifocal bacterial pneumonia, (SBI = 2) |
15 | 17 / M | C2 | Undetectable CH50, undetectable C2 level and function; (C1, C3-C9 levels normal) | Streptococcus pneumoniae meningitis (SBI = 2) |
16 | 13 / M | C2 | Undetectable CH50, undetectable C2 level and function; (C1, C3-C9 levels normal) | Streptococcal bacteremia, Hemophilus influenza pneumonia (SBI = 2) |
17b | 18 / F | C2 | Undetectable CH50, undetectable C2 level and function; (C3, C4 levels normal) | Neisseria meningitidis septic arthritis, spontaneous bacterial peritonitis (SBI = 2) |
18 | 5 / M | C2 | Undetectable CH50, undetectable C2 level and function; (C1, C3, C4 levels normal) | Recurrent episodes of Streptococcus pneumoniae bacteremia (SBI = 6) |