Efficacy and safety of intraarticular corticosteroid injections in adolescents with juvenile idiopathic arthritis in the temporomandibular joint: a Norwegian 2-year prospective multicenter pilot study

Frid, Paula; Augdal, Thomas A.; Larheim, Tore A.; Halbig, Josefine; Rypdal, Veronika; Songstad, Nils Thomas; Rosén, Annika; Tylleskär, Karin B.; Berstad, Johanna Rykke; Flatø, Berit; Stoustrup, Peter; Rosendahl, Karen; Kirkhus, Eva; Nordal, Ellen

doi:10.1186/s12969-020-00464-3

Pediatric Rheumatology

Table 4 Summary characteristics, use of medication at baseline and outcome-response during 2-year follow-up in adolescents with (JIA) (n = 15) receiving (IACs) to the (TMJs) (n = 22)

From: Efficacy and safety of intraarticular corticosteroid injections in adolescents with juvenile idiopathic arthritis in the temporomandibular joint: a Norwegian 2-year prospective multicenter pilot study

Case	M/F	Age Onset	Age Inj	Dose inj (mg)	Medic (T0)	Medic (T1)	Medic (T2)	Medic (T3)	MIO	Pain index	MRI additive inflammatory domain^a	MRI Progressive inflammation^a	MRI additive damage domain^a	MRI progressive osseous deformity^a	Comments
1	M	10	10	6	MTX	MTX	MTX		T0: 48 T1: 42 T2: 48 T3: -	T0: 6 T1 T2: 2 T3: -	T0: 6 T1: 4 T2: 6 T3: -	T0: 3 T1: 3 T2: 4 T3: -	T0: 3 T1: 4 T2: 4 T3: -	T0: 3 T1: 3 T2: 4 T3: -	Bilateral IACs Mandibular trauma between T1 and T2
2	F	17	17	8	MTX	BioCo	BioCo	BioCo	T0: 40 T1: - T2: 37 T3: -	T0: 0 T1: - T2: - T3: -	T0: 3 T1: 2 T2: 5 T3: 1	T0: 3 T1: 2 T2: 3 T3: 1	T0: 4 T1: 4 T2: 3 T3: 3	T0: 3 T1: 3 T2: 3 T3: 3	Unilateral IACs
3	F	11	11	8	MTX	MTX	BioCo		T0: 32 T1: 35 T2: 30 T3: -	T0: 9 T1: 0 T2: 0 T3: -	T0: 5 T1: 5 T2: 5 T3: -	T0: 3 T1: 3 T2: 3 T3: -	T0: 3 T1: 3 T2: 2 T3: -	T0: 3 T1: 2 T2: 0 T3: -	Unilateral IACs
4	F	13	14	20	No DMARD	No DMARD	No DMARD	No DMARD	T0: 44 T1: 48 T2: 41 T3: 47	T0: 0 T1: 0 T2: 9 T3: 0	T0: 4 T1: 2 T2: - T3: - T4: -	T0: 4 T1: 1 T2: - T3: 1 T4: 2	T0: 2 T1: 4 T2: 5 T3: 4 T4: 4	T0: 2 T1: 2 T2: 3 T3: 3 T4: 3	Unilateral repeated IACs (13 months interval)
5	F	9	15	20	BioCo		BioCo		T0: 48 T1: - T2: - T3: -	T0: 3 T1: - T2: - T3: 0	T0: 6 T1: - T2: 6 T3: -	T0: 3 T1: - T2: 3 T3: -	T0: 1 T1: - T2: 4 T3: -	T0: 0 T1: - T2: 2 T3: -	Unilateral IACs
6	F	9	14	10	BioCo	BioCo	BioCo	BioCo	T0: 46 T1: 45 T2: 47 T3: 47	T0: 5.5 T1: 2 T2: 0 T3: 0	T0: 1 T1: 1 T2: 1 T3: 1	T0: 1 T1: 1 T2: 1 T3: 1	T0: 0 T1: 0 T2: 0 T3: 0	T0: 0 T1: 0 T2: 0 T3: 0	Bilateral IACs
7	F	2	15	20	No DMARD	No DMARD	No DMARD	MTX	T0: 36 T1: 44 T2: 44 T3: 44	T0: 36 T1: 10 T2: 6 T3: 0	T0: 3 T1: 3 T2: 3 T3: 1	T0: 1 T1: 1 T2: 2 T3: 1	T0: 1 T1: 2 T2: 1 T3: 1	T0: 0 T1: 1 T2: 0 T3: 0	Bilateral IACs
8	F	15	16	40^b	No DMARD	No DMARD	MTX		T0: 45 T1: 46 T2: 50 T3: -	T0: 0 T1: 0 T2: 12 T3: -	T0: 2 T1: 2 T2: 2 T3: -	T0: 2 T1: 2 T2: 2 T3: -	T0: 4 T1: 4 T2: 4 T3: -	T0: 2 T1: 2 T2: 2 T3: -	Unilateral IACs
9	F	0	15	20	BioCo	BioCo	BioCo	No DMARD	T0: 49 T1: 54 T2: 54 T3: 45	T0: 0 T1: 5 T2: 0 T3: -	T0: 2 T1: 0 T2: 2 T3: 2	T0: 2 T1: 0 T2: 2 T3: 2	T0: 4 T1: 2 T2: 2 T3: 2	T0: 2 T1: 2 T2: 2 T3: 2	Unilateral IACs
10	F	15	16	20	No DMARD	No DMARD	MTX	MTX	T0: 45 T1: 44 T2: 49 T3: 48	T0: 12 T1: 22.5 T2: 0 T3: 6	T0: 5 T1: 6 T2: 4 T3: 2 T4: 3	T0: 3 T1: 3 T2: 3 T3: 1 T4: 3	T0: 3 T1: 3 T2: 3 T3: 4 T4: 3	T0: 3 T1: 3 T2: 3 T3: 3 T4: 3	Unilateral repeated IACs (11 months interval)
11	M	11	16	20	No DMARD	No DMARD	No DMARD	No DMARD	T0: 55 T1: 55 T2: 62 T3: 63	T0: 0 T1: 0 T2: 0 T3: 0	T0: 5 T1: 4 T2: 2 T3: 5	T0: 2 T1: 1 T2: 1 T3: 2	T0: 3 T1: 3 T2: 3 T3: 3	T0: 3 T1: 2 T2: 2 T3: 2	Unilateral injection
12	M	8	9	10	BioCo	BioCo	BioCo	BioCo	T0: 34 T1: 40 T2: 41 T3: 45	T0: 7.5 T1: 0 T2: 0 T3: 0	T0: 7 T1: 3 T2: 1 T3: 0	T0: 3 T1: 3 T2: 1 T3: 0	T0: 0 T1: 0 T2: 0 T3: 0	T0: 0 T1: 0 T2: 0 T3: 0	Bilateral IACs
13	F	14	15	16	BioCo	BioCo	BioCo	BioCo	T0: 42 T1: 44 T2: 45 T3: 46	T0: 21 T1: 14 T2: 2.5 T3: 5	T0: 6 T1: 6 T2: 5 T3: 5	T0: 3 T1: 3 T2: 3 T3: 3	T0: 5 T1: 5 T2: 5 T3: 5	T0: 3 T1: 3 T2: 3 T3: 3	Unilateral IACs
14	F	5	11	20	BioCo	BioCo	BioCo	BioCo	T0: 43 T1: 45 T2: 44 T3: 48	T0: 13 T1: 9 T2: 9 T3: 12	T0: 5 T1: - T2: 4 T3: 3	T0: 3 T1: - T2: 3 T3: 3	T0: 3 T1: 2 T2: 2 T3: -	T0: 3 T1: 3 T2: 3 T3: 3	Unilateral IACs
15	F	13	15	20	No DMARD	-	No DMARD	MTX	T0: 35 T1: 45 T2: 45 T3: 45	T0: 32 T1: - T2: 8 T3: 3	T0: 6 T1: 6 T2: 4 T3: 3	T0: 3 T1: 3 T2: 4 T3: 2	T0: 3 T1: 3 T2: 3 T3: 3	T0: 3 T1: 3 T2: 3 T3: 3	Bilateral IACs

^aAdditive and progressive MRI score [40, 41]
^bMetylprednisolone acetate
Inj injection, Medic medication, MIO maximal incisal opening, MRI magnetic resonance imaging, FU follow-up, MTX methotrexate, BioCo biologics alone or in combination with other, DMARDs disease modifying antirheumatic drugs, JIA juvenile idiopathic arthritis, TMJ temporomandibular joint, IACs intraarticular corticosteroid injections; T0 = Pre-injection, T1 = 2-months follow-up, T2 = 1-year follow-up, T3 = 2-year follow-up; − missing data " - "

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