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Table 3 Additive and progressive scoring system for assessment of inflammation and damage in the temporomandibular joint (TMJ) by magnetic resonance imaging (MRI) in 15 adolescents with juvenile idiopathic arthritis (JIA) and TMJ-arthritis receiving intraarticular corticosteroids (IACs)

From: Efficacy and safety of intraarticular corticosteroid injections in adolescents with juvenile idiopathic arthritis in the temporomandibular joint: a Norwegian 2-year prospective multicenter pilot study

 

Pre- injection (T0)

2- months FU (T1)

1-year FU (T2)

2-year FU (T3)

p-value

Mean months after IACs (SD)

0

n = 15

2.4 ± 1.6

n = 14

12.3 ± 1.5

n = 15

21.5 ± 2.6

n = 11

 

Additive Inflammatory domain: (Bone marrow edema, bone marrow enhancement, Joint effusion, Synovial thickening, Joint enhancement)

4.4 ± 1.8

3.4 ± 2.0 n = 13

3.6 ± 1.7 n = 14

2.3 ± 1.7 n = 10

0.040* a

Bone marrow edema

0.3 ± 0.5

0.1 ± 0.3

0.1 ± 0.4 n = 14

0.0 ± 0.0 n = 10

0.500* b

Bone marrow enhancement

0.4 ± 0.5

0.2 ± 0.4 n = 13

0.1 ± 0.4 n = 14

0.0 ± 0.0 n = 11

0.250* b

Joint effusion

0.8 ± 0.9

0.7 ± 0.8 n = 14

0.6 ± 0.9 n = 14

0.3 ± 0.7 n = 10

0.705* a

Synovial thickening

1.0 ± 0.8

1.0 ± 0.8 n = 14

1.0 ± 0.8 n = 14

0.7 ± 0.8 n = 10

1.000* a

Joint enhancement

1.9 ± 0.3

1.5 ± 0.7 n = 13

1.8 ± 0.4 n = 14

1.3 ± 0.6 n = 11

0.059* a

Additive Damage domain: (Condylar flattening, erosions, disc abnormalities)

2.6 ± 1.5

2.8 ± 1.5 n = 14

2.7 ± 1.6

2.5 ± 1.7 n = 10

1.000** a

Condylar flattening

1.3 ± 0.9

1.6 ± 0.8 n = 14

1.5 ± 0.9

1.5 ± 0.9 n = 11

0.157** a

Erosions

0.6 ± 0.7

0.6 ± 0.8 n = 14

0.5 ± 0.8

0.4 ± 0.7 n = 10

0.655** a

Disc abnormalities

0.7 ± 0.5

0.6 ± 0.5 n = 14

0.7 ± 0.5

0.7 ± 0.5 n = 11

1.000** b

Progressive inflammation

2.6 ± 0.8

2.0 ± 1.1 n = 13

2.5 ± 1.0 n = 14

1.5 ± 0.9 n = 11

0.066* a

Progressive osseous deformity

2.0 ± 1.3

2.1 ± 1.1 n = 14

2.0 ± 1.4

2.0 ± 1.3 n = 11

1.000** a

  1. Values are the mean ± SD unless indicated otherwise. N = 15 unless indicated otherwise. aWilcoxon signed-rank test. bMcNemar chi square test. *P ≤ 0.05 considered statistically significant between T0-T1 and ** between T0-T3. Each joint is scored independently (the worst joint is chosen when bilateral injection), with possible total scores ranging from 0 to 8 in the Additive inflammatory scoring system and 0–5 in the Additative damage domain, and 0–4 in the Progressive scoring system according to (Tolend et al.) [40] and (Kellenberger et al.) [41]; 2 patients received repeated injection on the same side, 5 patients received bilateral injection
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