TY - JOUR AU - Roszkiewicz, Justyna AU - Swacha, Zbigniew AU - Smolewska, Elżbieta PY - 2020 DA - 2020/08/12 TI - Prefilled pen versus prefilled syringe: a pilot study evaluating two different methods of methotrexate subcutaneous injection in patients with JIA JO - Pediatric Rheumatology SP - 64 VL - 18 IS - 1 AB - Methotrexate is the most commonly used disease-modifying antirheumatic drug recommended in the treatment of juvenile idiopathic arthritis. It can be administered orally or subcutaneously, the latter method is associated with fewer side effects and higher drug bioavailability. Nevertheless, the pain associated with injection is a considerable drawback of this treatment option in the pediatric population. Currently, there are two single-use subcutaneous injection devices available: the prefilled syringe and the prefilled pen. This prospective, two-sequence crossover study aimed to compare ease of use, frequency of therapy side effects, injection-site pain and parent/patient preference of those methotrexate parenteral delivery systems. SN - 1546-0096 UR - https://doi.org/10.1186/s12969-020-00455-4 DO - 10.1186/s12969-020-00455-4 ID - Roszkiewicz2020 ER -