Fig. 4

Serum from JIA adult patients in remission induces alterations in PBMCs, endothelial cells and adipocytes compared to HDs serum. a Relative gene expression of inflammatory mediators in PBMCs. b Relative gene expression of adipokines in PBMCs. c Relative gene expression of oxidative stress markers in PBMCs. d Relative gene expression of inflammatory mediators in HUVECs. e Relative gene expression of oxidative stress markers in HUVECs. f Relative gene expression of adhesion molecules in HUVECs. g Relative gene expression of inflammatory mediators in adipocytes. h Relative gene expression of adipokines in adipocytes. TNF-α: tumor necrosis factor-α; IL-1β: interleukin-1β; IL-6: interleukin-6; IL-8: interleukin-8; IFN-γ: interferon-γ; MCP-1: monocyte chemoattractant protein-1; TLR-2: toll like receptor-2; TLR-4: toll like receptor-4; LEP: Leptin; ADIPOQ: adiponectin; VISF: visfatin; RES: resistin; SOD-1: superoxide dismutase-1; SOD-2: superoxide dismutase-2; iNOS: inducible nitric oxide synthase; eNOS: endothelial nitric oxide synthase; GPX-1: glutathione peroxidase-1; VEGF-A: vascular endothelial growth factor-A. ^*Significant differences vs. HDs serum (p < 0.05)