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Table 1 Lung Diseases Caused by Macrophage Dysfunction

From: Proceedings from the 2nd Next Gen Therapies for Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome symposium held on October 3-4, 2019

Disease

Macrophage Dysfunction

Pulmonary Alveolar Proteinosis (PAP)

Surfactant accumulation in alveolar macrophages and alveoli

Lipoid Pneumonia

Lipid-laden macrophages and accumulation of intra-alveolar lipids

House Dust Mite + Virus-induced Asthma

Up-regulated apolipoprotein E (APOE) production by alveolar macrophages with resultant NLRP3 inflammasome activation and secretion of mature IL-1β

High-fat Diet-induced Lung Disease

Lipid-laden macrophages, increased lung cholesterol content, increased pro-inflammatory cytokines (interferon-γ, TNF and IL-6).