Disease | Macrophage Dysfunction |
---|---|
Pulmonary Alveolar Proteinosis (PAP) | Surfactant accumulation in alveolar macrophages and alveoli |
Lipoid Pneumonia | Lipid-laden macrophages and accumulation of intra-alveolar lipids |
House Dust Mite + Virus-induced Asthma | Up-regulated apolipoprotein E (APOE) production by alveolar macrophages with resultant NLRP3 inflammasome activation and secretion of mature IL-1β |
High-fat Diet-induced Lung Disease | Lipid-laden macrophages, increased lung cholesterol content, increased pro-inflammatory cytokines (interferon-γ, TNF and IL-6). |