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Fig. 4 | Pediatric Rheumatology

Fig. 4

From: C-type natriuretic peptide stimulates osteoblastic proliferation and collagen-X expression but suppresses fibroblast growth factor-23 expression in vitro

Fig. 4

Immunofluorescence staining of Col-X, FGF-23, FGFR-1 and Klotho protein in osteoblasts. Representative microscope images of cells on the coverslips with DAPI-stained nuclei (blue) and Col-X staining (green)/FGF-23 staining (red)/FGFR-1staining (red)/Klotho staining (red). Original magnification, × 400. The scale bar is 20 μm. a Col-X, c FGF-23, e FGFR-1 and g Klotho. Fluorescence intensities of Col-X, FGF-23, FGFR-1 and Klotho. b Col-X, d FGF-23, f FGFR-1 and h Klotho. Data are presented as the mean ± SD. *P < 0.05, significantly different from the corresponding control group (0 pM CNP); ∆P < 0.05, significantly different from the corresponding low-dose group (10 pM CNP)

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