Prevalence (%) | <  18 years | ≥ 18 years | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
MarketScan | PharMetrics | MarketScan | PharMetrics | |||||||||
JIA (N = 8633) | ADHD (N = 38,967) | Odds ratio (95% CI) | JIA (N = 9155) | ADHD (N = 41,264) | Odds ratio (95% CI) | JIA (N = 5789) | ADHD (N = 27,288) | Odds ratio (95% CI) | JIA (N = 5638) | ADHD (N = 27,106) | Odds ratio (95% CI) | |
Addison disease | 0.17 | 0.03 | 6.16 (2.83, 13.42) | 0.11 | 0.04 | 2.51 (1.16, 5.43) | 0.66 | 0.14 | 4.87 (3.09, 7.66) | 0.53 | 0.11 | 4.67 (2.83, 7.73) |
Alopecia areata | 0.10 | 0.05 | 2.03 (0.93, 4.46) | 0.15 | 0.06 | 2.43 (1.27, 4.65) | 0.10 | 0.10 | 1.09 (0.45, 2.64) | 0.18 | 0.11 | 1.66 (0.81, 3.41) |
Celiac disease | 0.51 | 0.13 | 3.99 (2.66, 5.98) | 0.54 | 0.14 | 3.82 (2.61, 5.60) | 0.24 | 0.18 | 1.32 (0.73, 2.39) | 0.53 | 0.20 | 2.63 (1.68, 4.11) |
Chronic glomerulonephritis | 0.12 | 0.00 | Inf | 0.08 | 0.00 | 31.57 (3.88, 256.56) | 0.05 | 0.02 | 2.36 (0.59, 9.43) | 0.09 | 0.00 | 24.06 (2.81, 205.96) |
Chronic urticaria | 1.69 | 0.50 | 3.40 (2.74, 4.22) | 1.42 | 0.70 | 2.04 (1.65, 2.51) | 1.45 | 0.58 | 2.53 (1.94, 3.30) | 1.35 | 0.67 | 2.03 (1.55, 2.66) |
Crohn’s disease | 1.11 | 0.07 | 16.84 (10.91, 25.99) | 1.06 | 0.08 | 12.99 (8.78, 19.2) | 1.52 | 0.40 | 3.88 (2.93, 5.16) | 1.17 | 0.37 | 3.23 (2.36, 4.42) |
Erythema nodosum | 0.09 | 0.01 | 12.05 (3.20, 45.4) | 0.09 | 0.01 | 9.02 (2.72, 29.96) | 0.03 | 0.04 | 0.94 (0.21, 4.3) | 0.14 | 0.02 | 7.7 (2.52, 23.55) |
Giant cell arteritis | 0.01 | 0.00 | 4.51 (0.28, 72.18) | 0.01 | 0.00 | Inf | 0.19 | 0.00 | Inf | 0.04 | 0.01 | 3.21 (0.54, 19.19) |
Graves’ disease | 0.12 | 0.04 | 3.23 (1.43, 7.27) | 0.10 | 0.06 | 1.69 (0.79, 3.64) | 0.35 | 0.16 | 2.15 (1.26, 3.65) | 0.28 | 0.20 | 1.45 (0.83, 2.54) |
Hashimoto’s thyroiditis/ autoimmune thyroid disease | 0.60 | 0.17 | 3.57 (2.48, 5.14) | 0.70 | 0.16 | 4.26 (3.03, 6.01) | 0.67 | 0.43 | 1.56 (1.09, 2.25) | 0.83 | 0.42 | 1.99 (1.42, 2.8) |
Hemolytic anemia | 0.37 | 0.05 | 6.90 (3.98, 11.97) | 0.24 | 0.05 | 4.52 (2.50, 8.16) | 0.50 | 0.07 | 6.86 (3.88, 12.14) | 0.30 | 0.06 | 5.46 (2.73, 10.94) |
Immune thrombocytopenia purpura/ thrombocytopenia purpura | 0.12 | 0.03 | 4.52 (1.88, 10.86) | 0.14 | 0.03 | 4.89 (2.23, 10.72) | 0.45 | 0.11 | 3.97 (2.35, 6.69) | 0.32 | 0.07 | 4.82 (2.51, 9.27) |
Interstitial lung disease/pulmonary fibrosis | 0.13 | 0.01 | 24.86 (5.51, 112.15) | 0.09 | 0.01 | 12.03 (3.19, 45.33) | 0.88 | 0.08 | 11.54 (6.94, 19.2) | 0.57 | 0.04 | 12.89 (6.63, 25.04) |
Morphea | 0.38 | 0.02 | 21.36 (9.45, 48.29) | 0.23 | 0.01 | 18.97 (7.15, 50.33) | 0.17 | 0.05 | 3.63 (1.59, 8.28) | 0.12 | 0.03 | 4.81 (1.69, 13.73) |
Multiple sclerosis | 0.01 | 0.01 | 2.26 (0.21, 24.90) | 0.03 | 0.01 | 3.38 (0.76, 15.11) | 0.45 | 0.30 | 1.5 (0.96, 2.33) | 0.32 | 0.21 | 1.52 (0.89, 2.58) |
Myasthenia gravis | 0.02 | 0.01 | 4.51 (0.64, 32.06) | 0.00 | 0.00 | Inf | 0.05 | 0.02 | 2.36 (0.59, 9.43) | 0.07 | 0.02 | 3.85 (1.03, 14.34) |
Pernicious anemia | 0.00 | 0.01 | 0 | 0.00 | 0.00 | 0 | 0.28 | 0.21 | 1.3 (0.75, 2.27) | 0.27 | 0.21 | 1.24 (0.7, 2.2) |
Polymyalgia rheumatic | 0.01 | 0.00 | Inf | 0.02 | 0.00 | 9.02 (0.82, 99.43) | 0.45 | 0.05 | 8.2 (4.34, 15.5) | 0.20 | 0.05 | 3.78 (1.72, 8.34) |
Polymyositis | 0.08 | 0.00 | Inf | 0.05 | 0.00 | 22.55 (2.63, 193.01) | 0.14 | 0.02 | 7.55 (2.47, 23.09) | 0.09 | 0.02 | 4.01 (1.22, 13.14) |
Primary biliary cirrhosis | 0.00 | 0.00 | 0 | 0.00 | 0.00 | Inf | 0.05 | 0.02 | 2.83 (0.68, 11.84) | 0.02 | 0.01 | 2.40 (0.22, 26.52) |
Psoriasis only | 0.73 | 0.09 | 8.42 (5.54, 12.78) | 0.71 | 0.12 | 5.89 (4.07, 8.53) | 1.21 | 0.53 | 2.31 (1.73, 3.08) | 1.45 | 0.50 | 2.93 (2.22, 3.86) |
Raynaud’s syndrome | 0.39 | 0.07 | 5.7 (3.44, 9.46) | 0.64 | 0.05 | 12.16 (7.45, 19.84) | 1.04 | 0.32 | 3.24 (2.33, 4.50) | 0.78 | 0.31 | 2.53 (1.76, 3.65) |
Scleritis and episcleritis | 0.22 | 0.01 | 17.19 (6.42, 46.04) | 0.23 | 0.02 | 13.55 (5.76, 31.88) | 0.35 | 0.07 | 5.25 (2.78, 9.94) | 0.34 | 0.09 | 3.66 (2.02, 6.66) |
Sjögren’s syndrome /sicca syndrome | 0.16 | 0.00 | Inf | 0.17 | 0.00 | 72.24 (9.58, 544.36) | 1.26 | 0.19 | 6.82 (4.76, 9.77) | 1.15 | 0.17 | 6.86 (4.70, 10.02) |
Systemic sclerosis/scleroderma | 0.25 | 0.01 | 24.89 (8.57, 72.23) | 0.22 | 0.00 | 90.34 (12.12, 673.22) | 0.28 | 0.03 | 10.8 (4.44, 26.26) | 0.20 | 0.02 | 8.83 (3.26, 23.88) |
Type 1 diabetes mellitus | 0.73 | 0.43 | 1.7 (1.27, 2.27) | 0.74 | 0.41 | 1.82 (1.37, 2.41) | 1.93 | 0.78 | 2.50 (1.98, 3.14) | 1.51 | 0.71 | 2.15 (1.66, 2.78) |
Ulcerative colitis | 0.41 | 0.05 | 8.34 (4.77, 14.59) | 0.36 | 0.06 | 6.49 (3.81, 11.05) | 1.19 | 0.33 | 3.69 (2.69, 5.06) | 0.67 | 0.28 | 2.41 (1.63, 3.57) |
Uveitis | 8.88 | 0.06 | 165.10 (108.97, 250.14) | 8.84 | 0.07 | 133.23 (92.47, 191.95) | 3.78 | 0.21 | 18.46 (13.8, 24.69) | 4.68 | 0.17 | 29.54 (21.51, 40.58) |
Vasculitis | 0.35 | 0.02 | 22.64 (9.42, 54.42) | 0.17 | 0.02 | 10.32 (4.24, 25.08) | 0.79 | 0.07 | 12.13 (7.03, 20.94) | 0.53 | 0.07 | 7.63 (4.29, 13.56) |
Vitiligo | 0.14 | 0.05 | 2.85 (1.39, 5.88) | 0.12 | 0.05 | 2.61 (1.24, 5.49) | 0.16 | 0.08 | 1.85 (0.85, 3.99) | 0.23 | 0.11 | 2.16 (1.12, 4.15) |